School of Biotechnology and Health Sciences, Wuyi University, Jiangmen 529020, China.
International Healthcare Innovation Institute, Jiangmen 529040, China.
Nutrients. 2020 Aug 28;12(9):2626. doi: 10.3390/nu12092626.
Nonalcoholic fatty liver disease (NAFLD) is the most common chronic liver disease that can progress from simple hepatic steatosis to nonalcoholic steatohepatitis (NASH), and even further to liver cirrhosis or liver cancer. Overconsumption of high fat and/or carbohydrate are among the most common lifestyle factors that drive the development and progression of NAFLD. This review evaluates recent reports on the involvement of autophagy and endoplasmic reticulum (ER) stress in the pathogenesis of NAFLD. Here, we reveal a mechanism of an intrinsically linked axis of impaired autophagy and unresolved ER stress that mediates the development and progression of NAFLD resulting from the overconsumption of high fat and/or carbohydrate.
非酒精性脂肪性肝病（NAFLD）是最常见的慢性肝病，可从单纯性肝脂肪变性进展为非酒精性脂肪性肝炎（NASH），甚至进一步发展为肝硬化或肝癌。高脂肪和/或高碳水化合物的过度摄入是导致 NAFLD 发生和发展的最常见生活方式因素之一。本综述评估了自噬和内质网（ER）应激在 NAFLD 发病机制中的作用的最新报告。在这里，我们揭示了一条内在联系的轴的机制，即自噬受损和未解决的 ER 应激，介导了由于高脂肪和/或高碳水化合物过度摄入导致的 NAFLD 的发生和发展。
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