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冠状动脉扩张患者急性心肌梗死的相关潜在因素。

Underlying factors relating to acute myocardial infarction for coronary artery ectasia patients.

作者信息

Sheng Qianqian, Zhao Huiqiang, Wu Shanshan, Liu Ruifeng

机构信息

Department of Cardiology, Beijing Friendship Hospital Affiliated to Capital Medical University, Beijing, China.

出版信息

Medicine (Baltimore). 2020 Sep 4;99(36):e21983. doi: 10.1097/MD.0000000000021983.

Abstract

Coronary artery ectasia (CAE) patients were more prone to present with acute myocardial infarction (AMI), this case-control research aimed to explore the underlying factors relating AMI for them.This study investigated a serial of 119 patients who underwent coronary angiography and were diagnosed as CAE between the years 2016 and 2017 at the Beijing Friendship Hospital; 32 of the patients developed AMI and 87 did not develop AMI. The possible factors relating to AMI, including disease history, cardiovascular risk factors, thrombotic condition, inflammation status, and coronary imaging characteristics, were comprehensively compared between CAE patients with and without AMI.CAE patients with AMI had a lower antiplatelet rate, a higher blood low-density lipoprotein cholesterol level, increased neutrophil to lymphocyte (NL) ratio, higher Gensini score, and larger proportions of Markis type II. Logistic regression analysis also indicated that AMI history, lower antiplatelet rate, higher NL ratio, higher low-density lipoprotein cholesterol level and Gensini score, as well as Markis type II were associated with AMI in CAE patients.AMI history, lower antiplatelet treatment rates, poor blood lipid control and higher coronary stenosis extent, higher inflammatory response, and Markis type II were closely related to the incidence of AMI in CAE patients.

摘要

冠状动脉扩张(CAE)患者更容易发生急性心肌梗死(AMI),本病例对照研究旨在探讨其发生AMI的潜在因素。本研究调查了2016年至2017年间在北京友谊医院接受冠状动脉造影并被诊断为CAE的119例患者;其中32例患者发生了AMI,87例未发生AMI。对发生AMI和未发生AMI的CAE患者,全面比较了与AMI相关的可能因素,包括病史、心血管危险因素、血栓形成情况、炎症状态和冠状动脉影像学特征。发生AMI的CAE患者抗血小板率较低、血液低密度脂蛋白胆固醇水平较高、中性粒细胞与淋巴细胞(NL)比值升高、Gensini评分较高,且Markis II型比例较大。Logistic回归分析还表明,AMI病史、较低的抗血小板率、较高的NL比值、较高的低密度脂蛋白胆固醇水平和Gensini评分以及Markis II型与CAE患者发生AMI有关。AMI病史、较低的抗血小板治疗率、血脂控制不佳、较高的冠状动脉狭窄程度、较高的炎症反应以及Markis II型与CAE患者AMI的发生率密切相关。

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本文引用的文献

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Is Coronary Artery Ectasia a Thrombotic Disease?冠状动脉扩张是一种血栓形成性疾病吗?
Angiology. 2019 Jan;70(1):62-68. doi: 10.1177/0003319718782807. Epub 2018 Jun 21.
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Coronary Artery Ectasia-A Review of Current Literature.冠状动脉扩张——当前文献综述
Curr Cardiol Rev. 2016;12(4):318-323. doi: 10.2174/1573403x12666160504100159.
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Characterization of vascular phenotype in patients with coronary artery ectasia: The role of endothelial dysfunction.
Int J Cardiol. 2016 Jul 15;215:138-9. doi: 10.1016/j.ijcard.2016.04.046. Epub 2016 Apr 13.
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The relationship between serum bilirubin concentration and coronary artery ectasia.血清胆红素浓度与冠状动脉扩张之间的关系。
Postepy Kardiol Interwencyjnej. 2015;11(3):202-5. doi: 10.5114/pwki.2015.54014. Epub 2015 Sep 28.
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Comparison of outcomes of diseased coronary arteries ectasia, stenosis and combined.病变冠状动脉扩张、狭窄及合并病变的预后比较。
Res Cardiovasc Med. 2015 Jan 20;4(1):e25206. doi: 10.5812/cardiovascmed.25206. eCollection 2015 Feb.

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