关于[未提及具体动物]动物模型胆汁淤积性肝损伤转录组分析的数据集。
Dataset on transcriptomic profiling of cholestatic liver injury in an and animal model.
作者信息
Gijbels Eva, Devisscher Lindsey, Vinken Mathieu
机构信息
Department of In Vitro Toxicology and Dermato-Cosmetology, Vrije Universiteit Brussel, Laarbeeklaan 103, 1090 Brussels, Belgium.
Basic and Applied Medical Sciences, Gut-Liver Immunopharmacology Unit, Faculty of Medicine and Health Sciences, Ghent University, Corneel Heymanslaan 10, 9000 Ghent, Belgium.
出版信息
Data Brief. 2020 Aug 7;32:106156. doi: 10.1016/j.dib.2020.106156. eCollection 2020 Oct.
The transcriptomic dataset (whole genome microarray Affymetrix Human U133 plus 2.0 and Affymetrix Mouse Genome 430 2.0) presented in this paper describes the differential gene expression profile of a human model of drug-induced cholestasis and a well-known mouse model of cholestasis. The model consists of human hepatoma HepaRG cells in monolayer configuration exposed to 3 different cholestatic drugs with or without bile acids. For modelling of cholestasis, mice were subjected to bile duct ligation surgery. Consecutive normalization, summarization and background adjustments have been made by means of Robust Multichip Average Express software.
本文中呈现的转录组数据集（全基因组微阵列Affymetrix Human U133 plus 2.0和Affymetrix Mouse Genome 430 2.0）描述了药物性胆汁淤积的人类模型和一种著名的胆汁淤积小鼠模型的差异基因表达谱。该人类模型由单层配置的人肝癌HepaRG细胞组成，使其暴露于3种不同的胆汁淤积药物，添加或不添加胆汁酸。为了建立胆汁淤积模型，对小鼠进行胆管结扎手术。通过稳健多芯片平均表达软件进行了连续标准化、汇总和背景调整。
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