Hoyer D
Preclinical Research, SANDOX LTD, Basle, Switzerland.
J Recept Res. 1988;8(1-4):59-81. doi: 10.3109/10799898809048978.
A short overview is given of the evidence supporting the existence of subtypes of 5-HT1 receptors. As 5-HT1 receptors were first described using radioligand binding studies, a brief description of 5-HT1A, 5-HT1B, 5-HT1C and 5-HT1D receptor binding is given. Then, recent data obtained in biochemical, electrophysiological, behavioural and other functional studies is compared to results obtained in radioligand binding studies. The paper shows that functional correlates do indeed exist for subtypes of 5-HT1 recognition sites; moreover, these are markedly different from the effects mediated by 5-HT2 (5-HT D) or 5-HT3 (5-HT M) receptors.
本文简要概述了支持5-羟色胺1（5-HT1）受体亚型存在的证据。由于5-HT1受体最初是通过放射性配体结合研究得以描述的，因此本文对5-HT1A、5-HT1B、5-HT1C和5-HT1D受体结合情况进行了简要描述。随后，将生物化学、电生理学、行为学及其他功能研究中获得的最新数据与放射性配体结合研究的结果进行了比较。本文表明，5-HT1识别位点亚型确实存在功能相关性；此外，这些相关性与5-HT2（5-HT D）或5-HT3（5-HT M）受体介导的效应明显不同。
