非典型宿主中的致命毛霉病和曲霉病：我们对混合性侵袭性霉菌感染了解多少？
Fatal Mucormycosis and Aspergillosis in an Atypical Host: What Do We Know about Mixed Invasive Mold Infections?
作者信息
Tsikala-Vafea Maria, Cao Weibiao, Olszewski Adam J, Donahue John E, Farmakiotis Dimitrios
机构信息
Division of Infectious Diseases, Department of Internal Medicine, The Warren Alpert Medical School of Brown University, Providence, RI 02903, USA.
Department of Pathology, The Warren Alpert Medical School of Brown University, Providence, RI 02903, USA.
出版信息
Case Rep Infect Dis. 2020 Aug 25;2020:8812528. doi: 10.1155/2020/8812528. eCollection 2020.
Mixed invasive mold infections (MIMIs) are considered rare. We present a case of fatal aspergillosis and mucormycosis in an elderly host with history of chronic lymphocytic leukemia (CLL) and potential mold exposures. Notably, he had no classic risk factors for IMI other than high-dose corticosteroids, which may be an important risk factor for (M)IMI, based on the current and previous reports. There is an urgent need for studies on the "net state of immunosuppression," environmental exposure as risk factors for (M)IMIs, and noninvasive fungal diagnostics.
混合性侵袭性霉菌感染（MIMIs）被认为较为罕见。我们报告一例老年宿主发生的致命性曲霉病和毛霉病，该宿主有慢性淋巴细胞白血病（CLL）病史且有潜在的霉菌暴露史。值得注意的是，除了大剂量皮质类固醇外，他没有侵袭性霉菌感染的典型危险因素，根据目前及既往报道，大剂量皮质类固醇可能是（混合性）侵袭性霉菌感染的一个重要危险因素。迫切需要开展关于“免疫抑制净状态”、作为（混合性）侵袭性霉菌感染危险因素的环境暴露以及非侵入性真菌诊断的研究。
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