Komatsu Teruya, Hara Akira, Date Naoki, Fujinaga Takuji, Kato Tatsuo
Department of General Thoracic Surgery, National Hospital Organization Nagara Medical Center, Gifu, Japan.
Department of Tumor Pathology, Gifu University Graduate School of Medicine, Gifu, Japan.
Int J Surg Case Rep. 2020;75:8-10. doi: 10.1016/j.ijscr.2020.08.020. Epub 2020 Aug 29.
Solitary pulmonary capillary hemangioma (SPCH) is a rare benign lung tumor that clinically resembles early lung cancer and precancerous pulmonary lesions that present with similar imaging manifestations.
The patient was a 54-year-old Japanese man who was referred to Nagara Medical Center with a ground glass opacity (GGO) lesion within the right upper lung that was incidentally detected on computed tomography. After 8 months of follow-up, video-assisted thoracoscopic segmental resection of the right upper lobe was performed with diagnostic and therapeutic intent. Pathologic examination of the resected specimen demonstrated thickening of the alveolar septum caused by the proliferation of capillary vessels. This lesion was positive for CD31 and CD34 and negative for thyroid transcription factor-1 and cytokeratin on immunohistochemical staining. The tumor was diagnosed as SPCH pathologically.
When radiological examination demonstrates a GGO in the lung, SPCH must be considered as one of the differential diagnoses. For a definitive diagnosis, pathological examination of a surgically resected specimen must be conducted.
This study describes a case of SPCH and a review of the literature.
孤立性肺毛细血管瘤(SPCH)是一种罕见的良性肺肿瘤,临床上类似于早期肺癌和具有相似影像学表现的癌前肺部病变。
该患者为一名54岁的日本男性,因计算机断层扫描偶然发现右上肺有磨玻璃密度影(GGO)病变而转诊至长良医疗中心。经过8个月的随访,为明确诊断及治疗进行了电视辅助胸腔镜右上叶节段性切除术。切除标本的病理检查显示,由于毛细血管增生导致肺泡间隔增厚。免疫组织化学染色显示该病变CD31和CD34呈阳性,甲状腺转录因子-1和细胞角蛋白呈阴性。该肿瘤经病理诊断为SPCH。
当影像学检查显示肺部有GGO时,SPCH必须被视为鉴别诊断之一。为明确诊断,必须对手术切除标本进行病理检查。
本研究描述了一例SPCH病例并对文献进行了综述。