An Mb1-Cre-driven oncogenic Kras mutation results in a mouse model of T-acute lymphoblastic leukemia/lymphoma with short latency and high penetrance.
作者信息
Junco Jacob J, Chen Taylor, Rashid Raushan, Terrell Maci, Gant Vincent U, Miller Matthew, Rau Rachel, Lacorazza H Daniel, Rabin Karen R
机构信息
Texas Children's Cancer Center, Department of Pediatrics, Baylor College of Medicine (BCM), Houston, TX, USA.
Department of Pathology & Immunology, BCM, Houston, TX, USA.
出版信息
Leukemia. 2021 Jun;35(6):1777-1781. doi: 10.1038/s41375-020-01036-w. Epub 2020 Sep 11.
Abstract
摘要
相似文献
1
An Mb1-Cre-driven oncogenic Kras mutation results in a mouse model of T-acute lymphoblastic leukemia/lymphoma with short latency and high penetrance.
Leukemia. 2021 Jun;35(6):1777-1781. doi: 10.1038/s41375-020-01036-w. Epub 2020 Sep 11.
2
Oncogenic Kras-induced leukemogeneis: hematopoietic stem cells as the initial target and lineage-specific progenitors as the potential targets for final leukemic transformation.
Blood. 2009 Feb 5;113(6):1304-14. doi: 10.1182/blood-2008-01-134262. Epub 2008 Dec 9.
3
Pdx1 expression in hematopoietic cells activates -mutation to drive leukemia in KC () mice.
Leuk Lymphoma. 2023 Jun;64(6):1112-1122. doi: 10.1080/10428194.2023.2202788. Epub 2023 Apr 20.
4
Wild-type KRAS inhibits oncogenic KRAS-induced T-ALL in mice.
Leukemia. 2015 May;29(5):1032-40. doi: 10.1038/leu.2014.315. Epub 2014 Nov 5.
5
Loss of CD44 attenuates aberrant GM-CSF signaling in Kras G12D hematopoietic progenitor/precursor cells and prolongs the survival of diseased animals.
Leukemia. 2013 Mar;27(3):754-7. doi: 10.1038/leu.2012.251. Epub 2012 Aug 31.
6
Notch1 gene mutations target KRAS G12D-expressing CD8+ cells and contribute to their leukemogenic transformation.
J Biol Chem. 2013 Jun 21;288(25):18219-27. doi: 10.1074/jbc.M113.475376. Epub 2013 May 14.
7
Nras Q61R/+ and Kras-/- cooperate to downregulate Rasgrp1 and promote lympho-myeloid leukemia in early T-cell precursors.
Blood. 2021 Jun 10;137(23):3259-3271. doi: 10.1182/blood.2020009082.
8
Mutant Ikzf1, KrasG12D, and Notch1 cooperate in T lineage leukemogenesis and modulate responses to targeted agents.
Proc Natl Acad Sci U S A. 2010 Mar 16;107(11):5106-11. doi: 10.1073/pnas.1001064107. Epub 2010 Mar 1.
9
A Pancreas-Specific Ptf1a-Driven Cre Mouse Line Causes Paternally Transmitted Germline Recombination.
Gastroenterology. 2021 Nov;161(5):1695-1697.e4. doi: 10.1053/j.gastro.2021.06.050. Epub 2021 Jun 24.
10
MAFB enhances oncogenic Notch signaling in T cell acute lymphoblastic leukemia.
Sci Signal. 2017 Nov 14;10(505):eaam6846. doi: 10.1126/scisignal.aam6846.
引用本文的文献
1
Efficacy of NAMPT inhibition in T-cell acute lymphoblastic leukemia.
PLoS One. 2025 Jun 17;20(6):e0324443. doi: 10.1371/journal.pone.0324443. eCollection 2025.
2
Pdx1 expression in hematopoietic cells activates -mutation to drive leukemia in KC () mice.
Leuk Lymphoma. 2023 Jun;64(6):1112-1122. doi: 10.1080/10428194.2023.2202788. Epub 2023 Apr 20.
3
Inhibition of the MAP2K7-JNK pathway with 5Z-7-oxozeaenol induces apoptosis in T-cell acute lymphoblastic leukemia.
Oncotarget. 2021 Aug 31;12(18):1787-1801. doi: 10.18632/oncotarget.28040.
本文引用的文献
1
RAS: Striking at the Core of the Oncogenic Circuitry.
Front Oncol. 2019 Sep 24;9:965. doi: 10.3389/fonc.2019.00965. eCollection 2019.
2
Drugging an undruggable pocket on KRAS.
Proc Natl Acad Sci U S A. 2019 Aug 6;116(32):15823-15829. doi: 10.1073/pnas.1904529116. Epub 2019 Jul 22.
3
Lmo2 expression defines tumor cell identity during T-cell leukemogenesis.
EMBO J. 2018 Jul 13;37(14). doi: 10.15252/embj.201798783. Epub 2018 Jun 7.
4
Constitutive Ras signaling and inactivation cooperate during the development of B-ALL in mice.
Blood Adv. 2017 Nov 21;1(25):2361-2374. doi: 10.1182/bloodadvances.2017012211. eCollection 2017 Nov 28.
5
Identification of a genetically defined ultra-high-risk group in relapsed pediatric T-lymphoblastic leukemia.
Blood Cancer J. 2017 Feb 3;7(2):e523. doi: 10.1038/bcj.2017.3.
6
High selective pressure for Notch1 mutations that induce Myc in T-cell acute lymphoblastic leukemia.
Blood. 2016 Nov 3;128(18):2229-2240. doi: 10.1182/blood-2016-01-692855. Epub 2016 Sep 26.
7
Mutational landscape, clonal evolution patterns, and role of RAS mutations in relapsed acute lymphoblastic leukemia.
Proc Natl Acad Sci U S A. 2016 Oct 4;113(40):11306-11311. doi: 10.1073/pnas.1608420113. Epub 2016 Sep 21.
8
Toward a NOTCH1/FBXW7/RAS/PTEN-based oncogenetic risk classification of adult T-cell acute lymphoblastic leukemia: a Group for Research in Adult Acute Lymphoblastic Leukemia study.
J Clin Oncol. 2013 Dec 1;31(34):4333-42. doi: 10.1200/JCO.2012.48.5292. Epub 2013 Oct 28.
9
The earliest thymic T cell progenitors sustain B cell and myeloid lineage potential.
Nat Immunol. 2012 Feb 19;13(4):412-9. doi: 10.1038/ni.2255.
10
Ly6d marks the earliest stage of B-cell specification and identifies the branchpoint between B-cell and T-cell development.
Genes Dev. 2009 Oct 15;23(20):2376-81. doi: 10.1101/gad.1836009.
Zotero 插件