Zhu Wan, Cao Wenxia, Zheng Xuting, Li Xuena, Li Yaming, Chen Baiyi, Zhang Jingping
The First Hospital of China Medical University, Shenyang, China.
The First Hospital of China Medical University, Shenyang, China
Clin Med (Lond). 2020 Sep;20(5):449-453. doi: 10.7861/clinmed.2020-0268.
This study investigated the clinical significance of F-fluorodeoxyglucose positron emission tomography / computed tomography (F-FDG PET/CT) in identifying the causes of fever of unknown origin (FUO).
Patients with a fever who received an F-FDG PET/CT examination were retrospectively selected. The means of the two groups were compared using an independent-samples t-test.
Among the 89 included patients, 66 were diagnosed using F-FDG PET/CT. The sensitivity, specificity and diagnostic accuracy of F-FDG PET/CT for the diagnosis of patients with FUO were 84.5%, 25.8%, and 64.0%, respectively. The detection rates of F-FDG PET/CT for neoplastic diseases, infectious diseases and non-infectious inflammatory diseases were 100%, 61.3%, and 75%, respectively. The difference in C-reactive protein (CRP) levels between the two groups was statistically significant.
F-FDG PET/CT has great clinical importance in diagnosing and identifying causes of FUO and improves the accuracy of FUO diagnosis when combined with serum CRP levels.
本研究调查了氟脱氧葡萄糖正电子发射断层扫描/计算机断层扫描（F-FDG PET/CT）在不明原因发热（FUO）病因诊断中的临床意义。
回顾性选取接受F-FDG PET/CT检查的发热患者。采用独立样本t检验比较两组的均值。
纳入的89例患者中，66例通过F-FDG PET/CT确诊。F-FDG PET/CT诊断FUO患者的敏感性、特异性和诊断准确性分别为84.5%、25.8%和64.0%。F-FDG PET/CT对肿瘤性疾病、感染性疾病和非感染性炎症性疾病的检出率分别为100%、61.3%和75%。两组间C反应蛋白（CRP）水平差异有统计学意义。
F-FDG PET/CT在FUO的诊断和病因鉴别中具有重要临床意义，与血清CRP水平联合可提高FUO诊断的准确性。
