Department of Biomedical and Dental Sciences and Morphofunctional Imaging, University of Messina , Messina, Italy.
Research Centre on Public Health (CESP), University of Milano-Bicocca , Milano, Italy.
Expert Rev Vaccines. 2020 Oct;19(10):919-936. doi: 10.1080/14760584.2020.1825951. Epub 2020 Oct 6.
Coronavirus disease (COVID-19), caused by severe acute respiratory syndrome coronavirus (SARS-CoV-2), has quickly spread around the world. This review will discuss the available immunologic and clinical evidence to support the benefit of the influenza, pneumococcal, and tuberculosis vaccines in the context of COVID-19 as well as to provide an overview on the COVID-19-specific vaccines that are in the development pipeline. In addition, implications for vaccination strategies from a public health perspective will be discussed. Some vaccines are being considered for their potentially beneficial role in preventing or improving the prognosis of COVID-19: influenza, pneumococcal and tuberculosis vaccines. These vaccines may have either direct effect on COVID-19 via different types of immune responses or indirect effects by reducing the burden of viral and bacterial respiratory diseases on individual patients and national healthcare system and by facilitating differential diagnoses with other viral/bacterial respiratory disease. On the other hand, a large number of candidate vaccines against SARS-CoV-2 are currently in the pipeline and undergoing phase I, II, and III clinical studies. As SARS-CoV-2 vaccines are expected to be marketed through accelerated regulatory pathways, vaccinovigilance as well as planning of a successful vaccination campaign will play a major role in protecting public health.
由严重急性呼吸系统综合症冠状病毒 2 型(SARS-CoV-2)引起的冠状病毒疾病(COVID-19)已迅速在全球蔓延。本综述将讨论现有的免疫学和临床证据,以支持在 COVID-19 背景下流感、肺炎球菌和结核病疫苗的益处,并概述正在开发管道中的 COVID-19 特异性疫苗。此外,还将从公共卫生角度讨论疫苗接种策略的意义。一些疫苗因其在预防或改善 COVID-19 预后方面的潜在益处而被考虑使用:流感、肺炎球菌和结核病疫苗。这些疫苗可能通过不同类型的免疫反应对 COVID-19 产生直接影响,或者通过减轻个体患者和国家医疗保健系统中病毒和细菌性呼吸道疾病的负担,以及通过与其他病毒性/细菌性呼吸道疾病进行鉴别诊断来产生间接影响。另一方面,目前有大量针对 SARS-CoV-2 的候选疫苗正在研发中,并正在进行 I、II 和 III 期临床试验。由于预计 SARS-CoV-2 疫苗将通过加速监管途径上市,疫苗监测以及成功疫苗接种活动的规划将在保护公众健康方面发挥重要作用。