理解和识别心脏淀粉样变性。

Understanding and recognizing cardiac amyloidosis.

机构信息

Todd McVeigh practices in cardiothoracic intensive care at Duke University Hospital in Durham, N.C. Carolina Tennyson practices in advanced heart failure services at Duke University Hospital and is on the faculty at the Duke University School of Nursing. The authors have no potential conflicts of interest, financial or otherwise.

出版信息

JAAPA. 2020 Oct;33(10):16-20. doi: 10.1097/01.JAA.0000697236.11386.3a.

DOI:10.1097/01.JAA.0000697236.11386.3a

PMID:32941304

Abstract

Cardiac amyloidosis is an infiltrative abnormality that causes myocardial thickening and dysfunction. Historically, it has been underrecognized as a cause of heart failure and was often misdiagnosed. In the past decade, the cardiology community has improved the understanding of the subtypes of these protein-based infiltrates and how they play a role in heart failure. This article reviews the pathophysiology, presentation, diagnosis, and management of cardiac amyloidosis.

摘要

心脏淀粉样变是一种浸润性异常，可导致心肌增厚和功能障碍。从历史上看，它一直被低估为心力衰竭的病因，并且经常被误诊。在过去的十年中，心脏病学界提高了对这些基于蛋白的浸润物的亚型以及它们在心力衰竭中所起作用的认识。本文回顾了心脏淀粉样变性的病理生理学、临床表现、诊断和治疗。