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前房人工晶状体植入术后角膜失代偿的 Descemet 膜内皮角膜移植术。

Descemet membrane endothelial keratoplasty for corneal decompensation caused by a phakic anterior chamber intraocular lens implantation.

机构信息

State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-sen University, Guangzhou, 510060, China.

出版信息

Graefes Arch Clin Exp Ophthalmol. 2020 Dec;258(12):2761-2766. doi: 10.1007/s00417-020-04928-w. Epub 2020 Sep 18.

Abstract

PURPOSE

To describe the clinical outcomes of Descemet membrane endothelial keratoplasty combined with phacoemulsification/posterior chamber intraocular lens implantation (triple procedure) for treatment of corneal decompensation induced by a phakic anterior chamber intraocular lens (AC IOL) implantation.

METHODS

Ten patients (10 eyes) with corneal decompensation due to phakic AC IOL implantation that had undergone the triple procedure were included in this study. Among the 10 eyes, 5 eyes underwent explantation of AC IOL prior to the transplantation, and then underwent the triple procedure. The remaining 5 eyes with a phakic AC IOL in situ underwent the triple procedure with concurrent explantation of AC IOL. Corrected distance visual acuity (CDVA), subjective refraction, endothelial cell density (ECD), and complications were documented.

RESULTS

The triple procedure was performed across all eyes without any adverse events. The average CDVA improved from 1.32 ± 0.24 preoperatively to 0.15 ± 0.05 logarithm of the minimum angle of resolution (logMAR), which represents an improvement in Snellen equivalent from 20/400 (0.05) preoperatively to 20/28 (0.71) at 12 months after surgery. At 12 months, all eyes reached a CDVA of 20/32 (0.63) or better, and 50% of eyes reached a CDVA of 20/25 (0.8) or better. The mean donor ECD±SD was 2868.7 ± 67.9 cells/mm, which decreased to 1724.1 ± 84.6 cells/mm at 12 months, representing 39.9% of endothelial cell loss. Patients did not experience any severe adverse events.

CONCLUSION

The triple procedure is a safe and effective option for corneal decompensation induced by a phakic AC IOL implantation, helping achieve a satisfactory visual rehabilitation with few complications.

摘要

目的

描述行去内皮的 Descemet 膜内皮角膜移植术联合超声乳化白内障吸除术/后房型人工晶状体植入术(三联手术)治疗有晶状体眼前房人工晶状体(AC IOL)植入术后角膜失代偿的临床疗效。

方法

本研究纳入了 10 例(10 只眼)因有晶状体眼 AC IOL 植入术后角膜失代偿而行三联手术的患者。其中 5 只眼在移植前行 AC IOL 取出术,然后行三联手术;另外 5 只眼 AC IOL 在位,行三联手术的同时行 AC IOL 取出术。记录最佳矫正视力(BCVA)、主观屈光度、角膜内皮细胞密度(ECD)和并发症。

结果

所有眼均顺利完成三联手术,无不良事件发生。平均 BCVA 从术前的 1.32±0.24 提高到术后 12 个月的 0.15±0.05 最小分辨角对数视力(logMAR),即从术前的 20/400(0.05)提高到 20/28(0.71)。术后 12 个月,所有眼均达到 20/32(0.63)或更佳的 BCVA,50%的眼达到 20/25(0.8)或更佳的 BCVA。供体角膜 ECD 的平均(±SD)为 2868.7±67.9 个/平方毫米,术后 12 个月降至 1724.1±84.6 个/平方毫米,角膜内皮细胞丢失率为 39.9%。患者未发生任何严重不良事件。

结论

三联手术是治疗有晶状体眼 AC IOL 植入术后角膜失代偿的安全有效方法,可获得满意的视力康复,且并发症少。

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