轴手性和中心手性的芳基吲哚啉-3-酮的有机催化不对称合成。
Organocatalytic asymmetric synthesis of arylindolyl indolin-3-ones with both axial and central chirality.
机构信息
Key Laboratory of Bioorganic Phosphorus Chemistry and Chemical Biology (Ministry of Education), Department of Chemistry, Tsinghua University, Beijing 100084, P. R. China.
School of Chemistry and Chemical Engineering, Beijing Institute of Technology, Beijing 100081, P. R. China.
出版信息
Chem Commun (Camb). 2020 Oct 20;56(83):12648-12651. doi: 10.1039/d0cc05432a.
An efficient method for chiral phosphoric acid-catalyzed asymmetric synthesis of arylindolyl indolin-3-ones with both axial and central chirality has been developed via the reaction of 3-arylindoles with 2-aryl-3H-indol-3-ones, and the target products were obtained in high yields with excellent enantioselectivity and diastereoselectivity.
一种高效的手性磷酸催化不对称合成具有轴手性和中心手性的芳基吲哚基吲哚啉-3-酮的方法已经被开发出来，该方法通过 3-芳基吲哚与 2-芳基-3H-吲哚-3-酮的反应实现，目标产物以高产率、优异的对映选择性和非对映选择性得到。
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