血清白细胞介素-6 水平在葡萄膜炎患者中的诊断和预后作用。
Diagnostic and Prognostic Roles of Serum Interleukin-6 Levels in Patients with Uveitis.
机构信息
Massachusetts Eye Research and Surgery Institution, Waltham, MA, USA.
The Ocular Immunology and Uveitis Foundation, Waltham, MA, USA.
出版信息
Ocul Immunol Inflamm. 2022 Feb 17;30(2):457-462. doi: 10.1080/09273948.2020.1815799. Epub 2020 Sep 23.
PURPOSE
To examine the diagnostic and prognostic roles of serum interleukin-6 levels in patients with uveitis.
METHODS
This was a retrospective observational case series. Demographic and clinical characteristics were compared between Group One (sixty patients) with normal serum IL-6 levels and Group Two (twenty patients) with high serum interleukin-6 levels.
RESULTS
Mean IL-6 level was 1.77 ± 0.97 pg/ml and 10.2 ± 9.7 pg/ml in Group One and Group Two respectively. Age, presence of systemic disease, and mean number of flare-ups were statistically significant ( = .015, = .000, = .03, respectively). Multivariate analysis was performed on variables that were statistically significant in univariate analysis and showed that three variables had significant correlation with IL-6 levels in both groups: systemic disease (OR = 10.83, < .001), Age (OR = 0.95, = .03) and number of flare-ups (OR = 2.9, = .02).
CONCLUSION
Serum IL-6 levels can provide diagnostic and prognostic information in regard to the course of disease and its treatment.
目的
探讨血清白细胞介素-6（IL-6）水平在葡萄膜炎患者中的诊断和预后作用。
方法
这是一项回顾性观察性病例系列研究。比较了血清 IL-6 水平正常的第 1 组（60 例）和血清白细胞介素-6 水平升高的第 2 组（20 例）患者的人口统计学和临床特征。
结果
第 1 组和第 2 组的平均 IL-6 水平分别为 1.77±0.97pg/ml 和 10.2±9.7pg/ml。年龄、合并系统性疾病以及平均发作次数在统计学上均有显著差异（ =0.015， =0.000， =0.03，分别）。对单因素分析中具有统计学意义的变量进行多变量分析，结果显示，两组中三个变量与 IL-6 水平均有显著相关性：系统性疾病（OR=10.83， <0.001）、年龄（OR=0.95， =0.03）和发作次数（OR=2.9， =0.02）。
结论
血清 IL-6 水平可提供有关疾病过程及其治疗的诊断和预后信息。
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