在生理条件下咪唑选择性炔烃氨加成反应。
Imidazole-Selective Alkyne Hydroamination under Physiological Conditions.
机构信息
Center for New Directions in Organic Synthesis, Department of Chemistry, Hanyang University, 222 Wangsimni-ro, Seongdong-gu, Seoul 04763, Korea.
出版信息
Org Lett. 2020 Oct 2;22(19):7588-7593. doi: 10.1021/acs.orglett.0c02785. Epub 2020 Sep 23.
PMID:32966077
Abstract
Imidazole-selective intermolecular hydroamination reaction has been discovered. This unprecedented additive-free addition reaction proceeds in an exclusively regioselective and stereoselective manner with high atom economy under extremely mild reaction conditions.
摘要
发现了咪唑选择性的分子间氨加成反应。这种前所未有的、无添加剂的加成反应在极其温和的反应条件下，以高度的原子经济性，以完全区域和立体选择性的方式进行。
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