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血液酒精含量水平是否会影响老年创伤患者的临床结局?

Does Level of Blood Alcohol Content Affect Clinical Outcomes After Trauma in Older Adult Patients?

作者信息

Bryant Mary K, Reynolds Katherine, Brittain Connor, Patel Zachery, Reid Trista D S, Maine Rebecca G, Udekwu Pascal

机构信息

Department of Surgery, WakeMed Health & Hospitals, Raleigh, NC, USA.

6798 Department of Surgery, University of North Carolina at Chapel Hill, NC, USA.

出版信息

Am Surg. 2020 Sep;86(9):1106-1112. doi: 10.1177/0003134820943555. Epub 2020 Sep 23.

Abstract

INTRODUCTION

Preinjury alcohol use and older age have independently been associated with poor outcomes. This study examined whether higher levels of blood alcohol concentration (BAC) correlated with an increased likelihood of poor outcomes in older trauma patients.

METHODS

This was a retrospective cohort study of injured patients ≥65 years with BAC testing presenting to a Level 1 trauma center between 2015 and 2018. Patients were stratified by BAC at 4 thresholds of intoxication: BAC ≧10 mg/dL, BAC ≧80 mg/dL, BAC ≧150 mg/dL, and BAC ≧200 mg/dL. Propensity score matching using inverse probability of treatment weighting was used to estimate outcomes. Logistic and Poisson regression models were performed for each threshold of the BAC level with the matched cohort to assess clinical outcomes.

RESULTS

Of all older patients (n = 3112), 32.5% (n = 1012) had BAC testing. In the matched cohort of 883 patients (76.7 ± 8.2 years; 48.1% female), 111 (12.5%) had BAC ≧10 mg/dL, 83 (74.8%) had BAC ≧80 mg/dL, 60 (54.1%) had BAC ≧150 mg/dL, and 37 (33.3%) had BAC ≧200 mg/dL. Falls (60.5%) and motor vehicle crashes (28.9%) were the most common mechanisms of injury. Median (IQR) of Injury Severity Score (ISS) was 5 (1-10). The risk of severe injury (ISS ≧15) was similar between alcohol-positive and alcohol-negative patients (9.9% vs 15.0%, = .151). BAC ≧10 g/dL was not associated with length of stay, intensive care unit admission, or in-hospital complication, nor was any of the other 3 analyzed BAC thresholds.

CONCLUSION

Overall, any detectable BAC along and increasing thresholds of BAC was not associated with poor in-hospital outcomes of older patients after trauma. Alcohol screening was low in this population, and intoxication may bias injury assessment, leading to mistriage of older trauma patients.

摘要

引言

受伤前饮酒和高龄均与不良预后独立相关。本研究调查了较高的血液酒精浓度(BAC)是否与老年创伤患者不良预后可能性增加相关。

方法

这是一项对2015年至2018年间到一级创伤中心就诊且进行了BAC检测的≥65岁受伤患者的回顾性队列研究。患者按BAC在4个中毒阈值进行分层:BAC≥10mg/dL、BAC≥80mg/dL、BAC≥150mg/dL和BAC≥200mg/dL。使用治疗权重的逆概率进行倾向评分匹配以估计预后。对匹配队列中BAC水平的每个阈值进行逻辑回归和泊松回归模型分析以评估临床预后。

结果

在所有老年患者(n = 3112)中,32.5%(n = 1012)进行了BAC检测。在883例匹配队列患者(76.7±8.2岁;48.1%为女性)中,111例(12.5%)BAC≥10mg/dL,83例(74.8%)BAC≥80mg/dL,60例(54.1%)BAC≥150mg/dL,37例(33.3%)BAC≥200mg/dL。跌倒(60.5%)和机动车碰撞(28.9%)是最常见的受伤机制。损伤严重程度评分(ISS)的中位数(IQR)为5(1 - 10)。酒精阳性和酒精阴性患者中严重损伤(ISS≥15)的风险相似(9.9%对15.0%,P = 0.151)。BAC≥10g/dL与住院时间、重症监护病房入住或院内并发症无关,其他3个分析的BAC阈值也均无此关联。

结论

总体而言,任何可检测到的BAC以及不断升高的BAC阈值均与老年创伤患者创伤后不良院内预后无关。该人群中酒精筛查率较低,且中毒可能会影响损伤评估,导致老年创伤患者分诊错误。

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