Pediatric Urology and Regenerative Medicine Research Center, Section of Tissue Engineering and Stem Cells Therapy, Children's Hospital Medical Center, Tehran University of Medical Sciences, Tehran, Iran.
Pediatric Urology Research Center, Children's Medical Center, Pediatric Center of Excellence, No. 62, Dr. Qarib's St, Keshavarz Blvd, 1419433151, Tehran, Iran.
Int Urol Nephrol. 2021 Feb;53(2):191-198. doi: 10.1007/s11255-020-02648-y. Epub 2020 Sep 26.
To represent the 15 years' experience of an academic referral center for the reconstruction of bladder exstrophy-epispadias complex with a modified single-stage approach. Single-staged reconstruction techniques are commonly used for classic bladder exstrophy. However, combined bladder closure and epispadias repair have been taken into great consideration in patients with initially failed reconstruction or delayed primary closure.
A total of 49 boys underwent 1-stage bladder and epispadias repair with pubic bone adaptation and without the application of pelvic osteotomy. The mean ± SD age at surgery was 5.23 ± 2.04 months. Continence and social dryness were assessed in the follow-ups with 3 months intervals for the first year and biannually thereafter.
The mean ± SD of follow-up was 127.25 ± 71.32 months. Urethrocutaneous fistula, stricture, wound infection, and hemiglans were developed in six distinct patients. However, no other major complications were noted. Three patients (6.1%) remained incontinent; while 32 (65.3%) children were socially continent and 14 (28.6%) children were waiting for toilet training. All the patients without previous failed closure were socially continent, while all incontinent patients had two failed closures in their history. No patient was rendered hypospadiac.
Based on the experience of this institution, the application of single-stage reconstructive techniques can lead to continence, cosmetically pleasing appearance with promising outcomes, and reduction of overall operations, hospital stay and costs in the majority of cases as compared to multiple surgical procedures.
介绍一家学术转诊中心在采用改良的一期手术治疗膀胱外翻-尿道上裂复合畸形方面的 15 年经验。一期重建技术通常用于经典的膀胱外翻。然而,对于最初重建失败或延迟一期闭合的患者,已经考虑采用膀胱闭合和尿道上裂修复相结合的方法。
共 49 名男孩接受了一期膀胱和尿道上裂修复术,采用耻骨适应和不应用骨盆截骨术。手术时的平均年龄为 5.23 ± 2.04 个月。在随访中,以 3 个月为间隔进行了 1 年的评估,此后每半年评估一次。
平均随访时间为 127.25 ± 71.32 个月。6 名患者出现了尿道皮肤瘘、狭窄、伤口感染和半阴茎畸形等不同的并发症。但没有其他重大并发症。3 名患者(6.1%)仍存在尿失禁;32 名(65.3%)儿童社会功能正常,14 名(28.6%)儿童正在等待如厕训练。所有无先前失败闭合的患者均有社会功能正常,而所有尿失禁患者均有两次失败的闭合史。没有患者出现阴茎下曲。
根据本机构的经验,一期重建技术的应用可以在大多数情况下实现控尿、美容效果良好,并且与多次手术相比,减少了总体手术次数、住院时间和费用。