Trends and Development in the Antibiotic-Resistance of : A Scientometric Research Study (1991-2019).

OBJECTIVE

Data visualization software were used to display and analyze the research status, hotspot and development trend of the antibiotic-resistance of objectively and comprehensively, so as to provide guidance and reference for the research of the antibiotic-resistant .

MATERIALS AND METHODS

The data of relevant publications on antibiotic-resistant from 1991 to 2019 were retrieved from Web of Science (WOS) Core database. VOSviewer and CiteSpace software were used to conduct co-citation visualization network rendering and cluster analysis on the publications' years, authors, countries, institutions, keywords and citations.

RESULTS

A total of 3915 valid records on the study of antibiotic-resistant were retrieved. The number of relevant publications was increasing year after year. The United States is the most influential country in the field, which works closely with other countries and publishes most of the papers. University of Sydney is the leading institution in this area. Bonomo Robert A publishes most of the papers. There are the highest number of publications in the research areas of antimicrobial agents and chemotherapy. "Nucleotide sequence" and "outbreak" were once the hotspots in this field, but recently "bacteriophage", "biofilm" and "colistin resistance" have become the research hotspots.

CONCLUSION

Since 1991, the number of publications on antibiotic-resistant has grown rapidly, and various countries and institutions have paid close attention to the problem of antibiotic resistance. Countries, institutions and researchers, which have strong influential power, collaborate with each other closely. The future research direction of antibiotic-resistant should lie in the further breakthrough of antibacterial peptides, bacteriophage therapy, CRISPR system and various combined therapies.