基质金属蛋白酶-9 rs3918242 基因型对儿童白血病风险的贡献。

Contribution of Matrix Metalloproteinase-9 rs3918242 Genotypes to Childhood Leukemia Risk.

机构信息

Department of Pediatric Orthopedics, China Medical University Hospital, Taichung, Taiwan, R.O.C.

Graduate Institute of Biomedical Sciences, China Medical University, Taichung, Taiwan, R.O.C.

出版信息

Anticancer Res. 2020 Oct;40(10):5751-5756. doi: 10.21873/anticanres.14591.

DOI:10.21873/anticanres.14591

PMID:32988902

Abstract

BACKGROUND/AIM: A single study has shown positive association and genotype-phenotype correlation between metalloproteinase-9 (MMP-9) promoter genotypes and adult acute lymphocytic leukemia (ALL). However, there is no report about childhood ALL. Thus, this study aimed at examining the role of MMP-9 rs3918242 genotypes in childhood ALL risk.

PATIENTS AND METHODS

A total of 266 childhood ALL cases and 266 healthy controls in Taiwan were examined for their MMP-9 rs3918242 genotypes via polymerase chain reaction-restriction fragment length polymorphism methodology.

RESULTS

The MMP-9 rs3918242 CT or TT genotype carriers only had a slightly increased risk compared with CC carriers (p=0.6386 and 0.6005, respectively). The allelic frequency analysis also supported the idea that the variant T allele at MMP-9 rs3918242 is not differentially distributed between the case and control groups (p=0.4834).

CONCLUSION

MMP-9 rs3918242 genotypes may indirectly influence the risk of childhood ALL. Further validations in other populations and analysis of the detail mechanisms are needed.

摘要

背景/目的：一项研究表明，基质金属蛋白酶-9（MMP-9）启动子基因型与成人急性淋巴细胞白血病（ALL）之间存在阳性关联和基因型-表型相关性。然而，目前尚无关于儿童 ALL 的报道。因此，本研究旨在探讨 MMP-9 rs3918242 基因型在儿童 ALL 发病风险中的作用。