桂枝汤对糖尿病性心脏自主神经病变的影响：一项系统评价与Meta分析方案

Effects of Guizhi decoction for diabetic cardiac autonomic neuropathy: A protocol for a systematic review and meta-analysis.

作者信息

Chen Junmin, Cai Jiawei, Wei Mengya, Zhang Xiaoran, Zhong Min, Liu Min, Yu Yang, Chen Qiu

机构信息

Hospital of Chengdu University of Traditional Chinese Medicine, Chengdu.

College of acupuncture and massage, Chengdu University of Traditional Chinese Medicine , No 37 Shi-er-qiao Road, Chengdu, Sichuan Province, PR China.

出版信息

Medicine (Baltimore). 2020 Sep 25;99(39):e22317. doi: 10.1097/MD.0000000000022317.

DOI:10.1097/MD.0000000000022317

PMID:32991439

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7523786/

Abstract

BACKGROUND

Diabetic cardiac autonomic neuropathy (DCAN) is one of the serious complications of diabetes. The pathogenesis of DCAN has not been fully elucidated. There is currently no effective treatment for such chronic disease. Traditional Chinese medicine has a long clinical history for the prevention and treatment of diabetes and chronic complications, and it also shows certain advantages in the treatment of DCAN. Many clinical studies have confirmed that Chinese medicine Guizhi decoction can reduce the clinical symptoms and improve neuronal function of patients with DCAN. So we intend to conduct a systematic review further clarified the effectiveness and safety of Guizhi decoction for DCAN.

METHODS

We will search each database from the built-in until July 2020. The English literature mainly searches Cochrane Library, PubMed, EMBASE, and Web of Science, while the Chinese literature comes from CNKI, CBM, VIP, and Wangfang database. Simultaneously we will retrieval clinical registration tests and grey literatures. In this study, only the clinical randomized controlled trials (RCTs) were selected to evaluate the efficacy and safety of Guizhi decoction in the treatment of DCAN. The 2 researchers independently conducted literature selection, data extraction, and quality assessment. Statistical heterogeneity among studies will be evaluated using the Cochran Q test (x) and the I statistical value. We will utilize the Review Manage software V5.3.0 (The Nordic Cochrane Center, The Cochrane Collaboration, 2014, Copenhagen, Denmark) to statistically analyze all data.

ETHICS AND DISSEMINATION

This study is a protocol for a systematic review of Guizhi decoction as a treatment of DCAN patients.

RESULTS

This study will provide high-quality synthesis of effectiveness and safety of Guizhi decoction for DCAN.

CONCLUSION

This systematic review aims to provide new options for Guizhi decoction treatment of DCAN in terms of its efficacy and safety.

REGISTRATION NUMBER

INPLASY202080018.

摘要

背景

糖尿病性心脏自主神经病变（DCAN）是糖尿病严重并发症之一。DCAN的发病机制尚未完全阐明。目前尚无针对这种慢性病的有效治疗方法。中医在糖尿病及其慢性并发症的防治方面有着悠久的临床历史，在DCAN的治疗中也显示出一定优势。许多临床研究证实，中药桂枝汤可减轻DCAN患者的临床症状并改善神经功能。因此，我们打算进行一项系统评价，以进一步阐明桂枝汤治疗DCAN的有效性和安全性。

方法

我们将检索自建库至2020年7月的每个数据库。英文文献主要检索Cochrane图书馆、PubMed、EMBASE和Web of Science，中文文献来自中国知网、中国生物医学文献数据库、维普数据库和万方数据库。同时，我们将检索临床注册试验和灰色文献。本研究仅选择临床随机对照试验（RCT）来评估桂枝汤治疗DCAN的疗效和安全性。两名研究人员独立进行文献筛选、数据提取和质量评估。将使用Cochran Q检验（x）和I统计值评估研究间的统计异质性。我们将使用Review Manage软件V5.3.0（北欧Cochrane中心，Cochrane协作网，2014年，丹麦哥本哈根）对所有数据进行统计分析。