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医保受益人群中转移性非小细胞肺癌患者接受专科姑息治疗的时机、费用和生存结局。

Timing, Costs, and Survival Outcome of Specialty Palliative Care in Medicare Beneficiaries With Metastatic Non-Small-Cell Lung Cancer.

机构信息

Department of Health Services Research, Management and Policy, College of Public Health and Health Professions, University of Florida, Gainesville, FL.

Department of Health Outcomes and Behavior, Moffitt Cancer Center, Tampa, FL.

出版信息

JCO Oncol Pract. 2020 Dec;16(12):e1532-e1542. doi: 10.1200/OP.20.00298. Epub 2020 Oct 2.

Abstract

PURPOSE

ASCO recommends early integration of palliative care in treating patients diagnosed with metastatic lung cancer. Our study sought to examine utilization of timely specialty palliative care (SPC) and its association with survival and cost outcomes in patients diagnosed with metastatic non-small-cell lung cancer (NSCLC).

METHODS

The 2001-2015 SEER-Medicare data were used to determine the baseline characteristics and outcomes of 79,253 patients with metastatic NSCLC. The predictors of early SPC use were examined using logistic regression. Mean and adjusted total and SPC-related costs were calculated using generalized linear regression. We used Cox regression model to determine the survival outcomes by SPC service settings. All statistical tests were two sided.

RESULTS

The time from cancer diagnosis to the first SPC use has reduced significantly, from 13.7 weeks in 2001 to 8.3 weeks in 2015 ( < .001). SPC use was associated with lower health care costs compared with those who had no SPC, from -$3,180 in 2011 ( < .001) to -$1,285 in 2015 ( = .059). Outpatient SPC use was associated with improved survival compared with patients who received SPC in other settings (hazard ratio, 0.83; 95% CI, 0.79 to 0.88; < .001).

CONCLUSION

Patients diagnosed with metastatic NSCLC now have more timely SPC service utilization, which was demonstrated to be a cost-saving treatment. Strategies to improve outpatient palliative care use might be associated with longer survival in patients with metastatic NSCLC.

摘要

目的

ASCO 建议在治疗转移性肺癌患者时尽早纳入姑息治疗。我们的研究旨在探讨及时获得专科姑息治疗(SPC)的情况,并分析其与转移性非小细胞肺癌(NSCLC)患者的生存和成本结果之间的关系。

方法

我们使用 2001 年至 2015 年的 SEER-Medicare 数据来确定 79253 例转移性 NSCLC 患者的基线特征和结局。使用逻辑回归分析早期 SPC 使用的预测因素。使用广义线性回归计算平均和调整后的总费用和 SPC 相关费用。我们使用 Cox 回归模型来确定 SPC 服务设置下的生存结果。所有统计检验均为双侧检验。

结果

从癌症诊断到首次 SPC 使用的时间明显缩短,从 2001 年的 13.7 周缩短至 2015 年的 8.3 周( <.001)。与未接受 SPC 的患者相比,SPC 患者的医疗保健费用更低,2011 年为-3180 美元( <.001),2015 年为-1285 美元( =.059)。与在其他环境中接受 SPC 的患者相比,门诊 SPC 治疗与生存改善相关(风险比,0.83;95%CI,0.79 至 0.88; <.001)。

结论

目前诊断为转移性 NSCLC 的患者能更及时地获得 SPC 服务,这一治疗方法被证明是节省成本的。改善门诊姑息治疗使用的策略可能与转移性 NSCLC 患者的生存时间延长有关。

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