Department of Ophthalmology, Doheny Eye Institute, Los Angeles, California.
Department of Ophthalmology, David Geffen School of Medicine at UCLA, Los Angeles, California.
Retina. 2021 Apr 1;41(4):686-693. doi: 10.1097/IAE.0000000000002990.
To evaluate the association between choriocapillaris (CC) flow deficits and structural optical coherence tomography biomarkers and the progression of intermediate age-related macular degeneration (iAMD) to complete retinal pigment epithelial and outer retinal atrophy.
Retrospective analysis of consecutive patients with iAMD with a minimum follow-up of 12 months. Odds ratios of intraretinal hyperreflective foci, hyporeflective drusen cores, subretinal drusenoid deposits, the presence of drusen volume ≥0.03 mm3 within a central 3-mm circle, fellow eye with late stage of AMD, and CC flow deficits at baseline and months of follow-up were estimated from logistic regression.
A total of 112 eyes with iAMD were included. Eyes that progressed were significantly more likely to show intraretinal hyperreflective foci, hyporeflective drusen cores, and drusen volume ≥0.03 mm3. The CC flow deficit was also significantly greater in eyes that developed complete retinal pigment epithelial and outer retinal atrophy. Intraretinal hyperreflective foci, hyporeflective drusen cores, drusen volume ≥0.03 mm3, and higher CC flow deficits were significantly and independently associated with the development of complete retinal pigment epithelial and outer retinal atrophy.
The CC flow deficit was significantly greater in iAMD eyes that progressed to complete retinal pigment epithelial and outer retinal atrophy and remained an independent risk factor when structural optical coherence tomography biomarkers were considered. CC flow deficits may be useful for enhancing risk stratification and prognostication of patients with iAMD.
评估脉络膜毛细血管（CC）血流缺损与结构光相干断层扫描生物标志物之间的关系，以及它们与中间型年龄相关性黄斑变性（iAMD）进展为完全性视网膜色素上皮和外层视网膜萎缩的关系。
回顾性分析了连续患有 iAMD 的患者，这些患者的随访时间至少为 12 个月。使用逻辑回归估算了在基线和随访期间，视网膜内高反射性焦点、低反射性玻璃膜疣核心、视网膜下玻璃膜疣状沉积物、中央 3 毫米圈内存在体积≥0.03 毫米 3 的玻璃膜疣、对侧眼晚期 AMD 以及 CC 血流缺损的比值比（OR）。
共纳入 112 只患有 iAMD 的眼。进展的眼更有可能出现视网膜内高反射性焦点、低反射性玻璃膜疣核心和体积≥0.03 毫米 3 的玻璃膜疣。完全性视网膜色素上皮和外层视网膜萎缩的眼的 CC 血流缺损也明显更大。视网膜内高反射性焦点、低反射性玻璃膜疣核心、体积≥0.03 毫米 3 的玻璃膜疣和更高的 CC 血流缺损与完全性视网膜色素上皮和外层视网膜萎缩的发生显著相关，且独立相关。
进展为完全性视网膜色素上皮和外层视网膜萎缩的 iAMD 眼的 CC 血流缺损明显更大，而当考虑结构光相干断层扫描生物标志物时，其仍然是一个独立的危险因素。CC 血流缺损可能有助于增强 iAMD 患者的风险分层和预后评估。
Zotero 插件