Servicio de Urología, Complejo Hospitalario Universitario de Albacete, Albacete, España.
Facultad de Medicina de Albacete, Departamento de Ciencias Médicas, Área de Urología, Universidad de Castilla La Mancha, Albacete, España.
Actas Urol Esp (Engl Ed). 2020 Dec;44(10):692-700. doi: 10.1016/j.acuro.2020.08.001. Epub 2020 Oct 1.
Inflammatory markers have prognostic value in various tumors due to the role of inflammatory phenomena at different stages of tumor development. The aim of this study is to demonstrate the prognostic value of these markers, as well as other clinical and analytical variables in patients with metastatic castration-resistant prostate cancer (mCRPC).
Prospective cohort study carried out on 80 patients diagnosed with mCRPC. Clinical and analytical data were collected, and the following inflammatory markers were estimated: Absolute Neutrophil Count (ANC), Neutrophil-Lymphocyte Ratio (NLR), Total Platelet Count (TPC), Platelet-Lymphocyte Ratio (PLR), Lymphocyte-Monocyte Ratio (LMR) and Systemic Inflammation Index (SII). The values of albumin, hemoglobin (Hb), alkaline phosphatase (ALP) and lactate dehydrogenase (LDH) were also determined.
Patients with ANC>7500, NLR>3, PLR>150, LMR>3 and/or SII>535,000, presented significantly lower median survival time than the remaining patients, and TPC was the only marker which did not show a significant association. Moreover, NLR, PLR and SII were inversely correlated with survival time. Patients with hypoalbuminemia, anemia, and elevated LDH values had significantly lower median survival time. Albumin and hemoglobin were directly correlated to overall survival time. The need for analgesia was also associated with shorter survival.
The values of certain inflammatory markers are associated with shorter survival time in patients with mCRPC, and their use in clinical practice can be considered to evaluate the prognosis and estimate survival.
炎症标志物在各种肿瘤中具有预后价值，这是由于炎症现象在肿瘤发展的不同阶段发挥作用。本研究旨在证明这些标志物以及其他临床和分析变量在转移性去势抵抗性前列腺癌（mCRPC）患者中的预后价值。
对 80 例诊断为 mCRPC 的患者进行前瞻性队列研究。收集临床和分析数据，并评估以下炎症标志物：绝对中性粒细胞计数（ANC）、中性粒细胞与淋巴细胞比值（NLR）、血小板总数（TPC）、血小板与淋巴细胞比值（PLR）、淋巴细胞与单核细胞比值（LMR）和全身炎症指数（SII）。还测定了白蛋白、血红蛋白（Hb）、碱性磷酸酶（ALP）和乳酸脱氢酶（LDH）的值。
ANC>7500、NLR>3、PLR>150、LMR>3 和/或 SII>535000 的患者中位生存时间明显短于其余患者，而 TPC 是唯一未显示出显著相关性的标志物。此外，NLR、PLR 和 SII 与生存时间呈负相关。低白蛋白血症、贫血和升高的 LDH 值的患者中位生存时间明显缩短。白蛋白和血红蛋白与总生存时间呈正相关。对镇痛的需求也与较短的生存时间相关。
某些炎症标志物的值与 mCRPC 患者的生存时间缩短相关，其在临床实践中的应用可用于评估预后和估计生存。
