人血浆中游离D-氨基酸与衰老及肾脏疾病的关系。

Free D-amino acids in human plasma in relation to senescence and renal diseases.

作者信息

Nagata Y, Akino T, Ohno K, Kataoka Y, Ueda T, Sakurai T, Shiroshita K, Yasuda T

出版信息

Clin Sci (Lond). 1987 Jul;73(1):105-8. doi: 10.1042/cs0730105.

Abstract

Minute but appreciable amounts of D-amino acids were detected in normal human plasma. The content was significantly higher in an elderly population (age 76 +/- 6 years, mean +/- SD, n = 41) than in a younger group (age 42 +/- 4 years, n = 26), i.e. 6.9 +/- 4.8 nmol/ml (mean +/- SD, range 0-18.8 nmol/ml) and 2.5 +/- 1.8 nmol/ml (range 0-6.3 nmol/ml) for the elderly and the younger groups, respectively. Elevation of plasma D-amino acid level was observed in a group of patients with renal disease (3.6-52.6 nmol/ml), in proportion to the serum level of creatinine (n = 50, r = 0.726, P less than 0.001), beta 2-microglobulin (n = 34, r = 0.551, P less than 0.005), and to glomerular filtration rate (n = 39, r = 0.556, P less than 0.001).

摘要

在正常人血浆中检测到微量但可检测到的D-氨基酸。老年人群（年龄76±6岁，均值±标准差，n = 41）中的含量显著高于年轻组（年龄42±4岁，n = 26），即老年组和年轻组的含量分别为6.9±4.8 nmol/ml（均值±标准差，范围0 - 18.8 nmol/ml）和2.5±1.8 nmol/ml（范围0 - 6.3 nmol/ml）。在一组肾病患者中观察到血浆D-氨基酸水平升高（3.6 - 52.6 nmol/ml），与血清肌酐水平（n = 50，r = 0.726，P < 0.001）、β2-微球蛋白水平（n = 34，r = 0.551，P < 0.005）以及肾小球滤过率（n = 39，r = 0.556，P < 0.001）成比例。