临床实验注册库检索在重症监护期刊系统综述中的应用不足：文献计量分析。

Clinical trial registry searches are under-utilized in systematic reviews from critical care journals: A bibliometric analysis.

机构信息

University of Texas Medical Branch, Department of Internal Medicine, Galveston, TX, USA.

Oklahoma State University Center for Health Sciences, College of Osteopathic Medicine, Tulsa, OK, USA.

出版信息

J Crit Care. 2021 Jun;63:175-178. doi: 10.1016/j.jcrc.2020.09.010. Epub 2020 Sep 17.

DOI:10.1016/j.jcrc.2020.09.010

PMID:33012585

Abstract

PURPOSE

Publication bias has a significant impact on the results of systematic reviews. Clinical trial registry searches, which include unpublished research, should be conducted when performing systematic reviews to reduce publication bias. We aimed to analyze the use of clinical trial registry searches in critical care systematic reviews.

METHODS

Systematic reviews published between 01/01/2010-02/18/2020 from the top 5 critical care journals were extracted from PubMed and screened for trial registry use. Additionally, of the studies not performing registry searches, we assessed ClinicalTrials.gov for potentially relevant trials that were missed by not performing a registry search.

RESULTS

Three hundred and twenty six systematic reviews were analyzed, of which 37 (11.3%) performed trial registry searches. Of the studies not performing clinical trial registry searches, 56% had at least 1 potentially relevant trial that was missed.

CONCLUSIONS

The omission of relevant, unpublished clinical trial results may be negatively impacting the accuracy of critical care systematic reviews. We recommend all systematic reviewers conduct clinical trial registry searches to reduce publication bias.

摘要

目的

发表偏倚对系统评价的结果有重大影响。进行系统评价时，应进行临床试验注册库检索，以纳入未发表的研究，从而减少发表偏倚。我们旨在分析在重症监护系统评价中使用临床试验注册库检索的情况。

方法

从 PubMed 中提取并筛选出 2010 年 1 月 1 日至 2020 年 2 月 18 日发表的排名前 5 的重症监护期刊的系统评价，以评估其对试验注册库的使用情况。此外，对于未进行注册库检索的研究，我们评估了 ClinicalTrials.gov 中是否存在因未进行注册库检索而遗漏的潜在相关试验。