Department of Life Science, Kindai University.
J Toxicol Sci. 2020;45(10):639-650. doi: 10.2131/jts.45.639.
Bisphenol A (BPA), an endocrine disruptor with estrogenic effects, is widely used as a raw material for manufacturing polycarbonate plastic and epoxy resins. Prenatal and postnatal exposure to BPA affects brain morphogenesis. However, the effects of prenatal and postnatal BPA exposure on postnatal neurogenesis in mice are poorly understood. In this study, we developed a mouse model of prenatal and postnatal BPA exposure and analyzed its effects on hippocampal neurogenesis. The hippocampal dentate gyrus is vulnerable to chemical exposure, as neurogenesis continues in this region even after birth. Our results showed that in mice, prenatal and postnatal BPA exposure decreased the number of type-1, 2a, 2b, and 3 neural progenitor cells, as well as in granule cells, in the hippocampal dentate gyrus on postnatal days 16 and 70. The effect of prenatal and postnatal BPA exposure on neural progenitors were affected at all differentiation stages. In addition, prenatal and postnatal BPA exposure affects the maintenance of long-term memory on postnatal day 70. Our results suggest that neurodevelopmental toxicity due to prenatal and postnatal BPA exposure might affect postnatal morphogenesis and functional development of the hippocampal dentate gyrus.
双酚 A（BPA）是一种具有雌激素作用的内分泌干扰物，被广泛用作制造聚碳酸酯塑料和环氧树脂的原料。产前和产后暴露于 BPA 会影响大脑形态发生。然而，产前和产后暴露于 BPA 对小鼠产后神经发生的影响知之甚少。在这项研究中，我们开发了一种产前和产后 BPA 暴露的小鼠模型，并分析了其对海马神经发生的影响。海马齿状回容易受到化学物质的暴露，因为即使在出生后，该区域的神经发生仍在继续。我们的结果表明，在小鼠中，产前和产后 BPA 暴露会减少海马齿状回中的 1 型、2a 型、2b 型和 3 型神经祖细胞以及颗粒细胞的数量，在出生后第 16 天和第 70 天。产前和产后 BPA 暴露对神经祖细胞的影响存在于所有分化阶段。此外，产前和产后 BPA 暴露会影响产后第 70 天的长期记忆的维持。我们的结果表明，产前和产后 BPA 暴露引起的神经发育毒性可能会影响海马齿状回的产后形态发生和功能发育。
