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多组学方法：改善囊性纤维化患者呼吸健康的关键？

Multi-Omics Approaches: The Key to Improving Respiratory Health in People With Cystic Fibrosis?

作者信息

Lee Andrew J, Einarsson Gisli G, Gilpin Deirdre F, Tunney Michael M

机构信息

Halo Research Group, Queen's University Belfast, Belfast, United Kingdom.

Centre for Experimental Medicine, School of Medicine, Dentistry and Biomedical Sciences, Queen's University Belfast, Belfast, United Kingdom.

出版信息

Front Pharmacol. 2020 Sep 3;11:569821. doi: 10.3389/fphar.2020.569821. eCollection 2020.

DOI:10.3389/fphar.2020.569821
PMID:33013411
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7509435/
Abstract

The advent of high-throughput multi-omics technologies has underpinned the expansion in lung microbiome research, increasing our understanding of the nature, complexity and significance of the polymicrobial communities harbored by people with CF (PWCF). Having established that structurally complex microbial communities exist within the airways, the focus of recent research has now widened to investigating the function and dynamics of the resident microbiota during disease as well as in health. With further refinement, multi-omics approaches present the opportunity to untangle the complex interplay between microbe-microbe and microbe-host interactions in the lung and the relationship with respiratory disease progression, offering invaluable opportunities to discover new therapeutic approaches for our management of airway infection in CF.

摘要

高通量多组学技术的出现推动了肺部微生物组研究的扩展，增进了我们对囊性纤维化患者（PWCF）所携带的多微生物群落的性质、复杂性和重要性的理解。在确定气道内存在结构复杂的微生物群落之后，近期研究的重点现已扩大到调查疾病期间以及健康状态下常驻微生物群的功能和动态变化。随着技术的进一步完善，多组学方法为理清肺部微生物-微生物和微生物-宿主相互作用之间的复杂关系以及与呼吸道疾病进展的关系提供了机会，为发现治疗囊性纤维化气道感染的新方法提供了宝贵契机。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0b29/7509435/11f23c2eb840/fphar-11-569821-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0b29/7509435/11f23c2eb840/fphar-11-569821-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0b29/7509435/11f23c2eb840/fphar-11-569821-g001.jpg

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Front Microbiol. 2020 Apr 15;11:695. doi: 10.3389/fmicb.2020.00695. eCollection 2020.
2
The Microbiome of the Nose-Friend or Foe?鼻腔微生物群——是友还是敌？
Allergy Rhinol (Providence). 2020 Mar 13;11:2152656720911605. doi: 10.1177/2152656720911605. eCollection 2020 Jan-Dec.
3
Respiratory microbiome and epithelial interactions shape immunity in the lungs.
依列卡福妥-替扎卡福妥-依伐卡福妥治疗后囊性纤维化肺部的纵向微生物和分子动力学
Res Sq. 2023 Sep 25:rs.3.rs-3356170. doi: 10.21203/rs.3.rs-3356170/v1.
4
Multiomic Investigations into Lung Health and Disease.肺部健康与疾病的多组学研究
Microorganisms. 2023 Aug 19;11(8):2116. doi: 10.3390/microorganisms11082116.
5
The development, validation, and testing of a high-precision bronchial epithelial lining fluid sampling device.一种高精度支气管上皮衬液采样装置的研发、验证及测试。
Front Med (Lausanne). 2023 Jul 26;10:1172622. doi: 10.3389/fmed.2023.1172622. eCollection 2023.
6
Pseudomonas aeruginosa in the Cystic Fibrosis Lung.铜绿假单胞菌在囊性纤维化肺中的作用。
Adv Exp Med Biol. 2022;1386:347-369. doi: 10.1007/978-3-031-08491-1_13.
7
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CNS Neurol Disord Drug Targets. 2019;18(9):687-694. doi: 10.2174/1871527318666191021145252.