Zhào Hóngyi, Wei Wei, Liu Yu, Gao Jiajia, Huang Yonghua
Department of Neurology, Chinese PLA General Hospital, Beijing, China.
Department of Neurology, Number 984 Hospital of the PLA, Beijing, China.
Front Med (Lausanne). 2020 Sep 4;7:397. doi: 10.3389/fmed.2020.00397. eCollection 2020.
Cognitive frailty (CF) is gaining an increasing amount of attention in geriatric research. CF refers to the co-occurrence of physical frailty and cognitive impairment in people without dementia. Neuroimaging of elderly people has revealed the presence of numerous white matter lesions, which is a typical biomarker of cerebral small vessel disease (SVD) on magnetic resonance images. The aim of the present study was to estimate the prevalence of CF in elderly Chinese patients with SVD. One hundred and thirty elderly patients with SVD were recruited for this cross-sectional observational study. Participants who met three to five of the Fried criteria of the physical frailty (PF) phenotype (shrinking, weakness, slowness, self-reported exhaustion, or low physical activity) were classified as having PF. Then, individuals with PF were defined as having CF if mild cognitive impairment was discovered by the Mini-Mental State Examination. Lastly, a series of cognitive function tests and the dual-task walking paradigm were examined. Based on the CF diagnostic criteria, the frequency of CF was 23.08% among elderly Chinese patients with SVD. Furthermore, CF-positive patients had a more significant SVD burden, based on magnetic resonance imaging findings. Logistic regression analysis, which was adjusted for age, sex, education, and comorbidities, showed that CF was negatively correlated with the dual-task walking speed in elderly people with SVD. Thus, SVD burden might be an indicator of CF phenotype. In elderly patients with SVD, CF was associated with dual task walking performance.
认知衰弱（CF）在老年医学研究中受到越来越多的关注。CF指的是在无痴呆症的人群中身体衰弱和认知障碍同时出现的情况。对老年人的神经影像学检查发现存在大量白质病变，这是磁共振成像上脑小血管疾病（SVD）的典型生物标志物。本研究的目的是评估中国老年SVD患者中CF的患病率。本横断面观察性研究招募了130例老年SVD患者。符合身体衰弱（PF）表型的Fried标准中的三到五项（体型缩小、虚弱、行动迟缓、自我报告的疲惫或低体力活动）的参与者被归类为患有PF。然后，如果简易精神状态检查发现轻度认知障碍，则将患有PF的个体定义为患有CF。最后，进行了一系列认知功能测试和双任务步行范式检查。根据CF诊断标准，中国老年SVD患者中CF的发生率为23.08%。此外，根据磁共振成像结果，CF阳性患者的SVD负担更重。在对年龄、性别、教育程度和合并症进行校正的逻辑回归分析中，结果显示CF与老年SVD患者的双任务步行速度呈负相关。因此，SVD负担可能是CF表型的一个指标。在老年SVD患者中，CF与双任务步行表现相关。
