Division of Hematology, Department of Human Pathology in Adulthood and Childhood "Gaetano Barresi", University of Messina, Messina, Italy.
Eur Rev Med Pharmacol Sci. 2020 Sep;24(18):9721-9738. doi: 10.26355/eurrev_202009_23064.
In 2019, an infection provoked by SARS-CoV-2 virus arose in Wuhan, China. Currently, there is still no definite and efficacious therapy for SARS-CoV-2 infection. Moreover, our understanding of the physiopathology of the infection, and risk elements for severity and mortality, is incomplete.
One largely neglected element that could affect prognosis of SARS-CoV-2 infection is the vitamin status of population. The purpose of this review is to evaluate whether a vitamin insufficiency could provoke an augmented risk of SARS-CoV-2 infection or the appearance of major complications. In particular, we evaluated the presence of studies related to the state and effects of vitamin D, C, B, and A in subjects with SARS-CoV-2 disease.
Although, actually, the interest in a possible use for vitamin supplementation in SARS-CoV-2 patients is essentially based on indirect data, we tried to examine the evidence about a favorable effect of vitamin supplementation in the therapy of the infection and its complications.
Supplements with vitamin A, B, C, D, and E could represent an inexpensive and sufficiently safe approach, and a useful therapeutic complement. However, solid clinical research data are expected to support such claim.
2019 年，中国武汉爆发了由 SARS-CoV-2 病毒引起的感染。目前，针对 SARS-CoV-2 感染仍没有明确有效的治疗方法。此外，我们对感染的病理生理学以及严重程度和死亡率的危险因素的了解还不完整。
一个可能影响 SARS-CoV-2 感染预后的被严重忽视的因素是人群的维生素状态。本综述的目的是评估维生素不足是否会增加 SARS-CoV-2 感染的风险或出现主要并发症。特别是，我们评估了与 SARS-CoV-2 疾病患者的维生素 D、C、B 和 A 状态和作用相关的研究。
尽管实际上，人们对维生素补充剂在 SARS-CoV-2 患者中的可能用途的兴趣主要基于间接数据，但我们仍试图研究维生素补充剂在治疗感染及其并发症方面的有益作用的证据。
维生素 A、B、C、D 和 E 的补充剂可能是一种廉价且足够安全的方法，也是一种有用的治疗补充剂。但是，仍需要有确凿的临床研究数据来支持这一说法。
