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用于 7T 波谱和波谱成像的具有类脑代谢物的逼真头形体模。

Realistic head-shaped phantom with brain-mimicking metabolites for 7 T spectroscopy and spectroscopic imaging.

机构信息

Life Sciences Core Facilities, Weizmann Institute of Science, Rehovot, Israel.

The Azrieli National Institute for Human Brain Imaging and Research, Weizmann Institute of Science, Rehovot, Israel.

出版信息

NMR Biomed. 2021 Jan;34(1):e4421. doi: 10.1002/nbm.4421. Epub 2020 Oct 4.

DOI:10.1002/nbm.4421
PMID:33015864
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7757235/
Abstract

PURPOSE

Moving to ultra-high fields (≥7 T), the inhomogeneity of both RF (B ) and static (B ) magnetic fields increases, which further motivates us to design a realistic head-shaped phantom, especially for spectroscopic imaging. Such phantoms provide images similar to the human brain and serve as a reliable tool for developing and examining methods in MRI. This study aims to develop and characterize a realistic head-shaped phantom filled with brain-mimicking metabolites for MRS and magnetic resonance spectroscopic imaging in a 7 T MRI scanner.

METHODS

A 3D head-shaped container with three sections-mimicking brain, muscle and precranial lipid-was constructed. The phantom was designed to provide robustness to heating, mechanical damage and leakage, with easy refilling. The head's shape and the agarose mixture were optimized to provide B and B distributions and T /T relaxation values similar to those of human brain. Eight brain-tissue-mimicking metabolites were included for spectroscopy. The phantom was evaluated for localized spectroscopy, fast spectroscopic imaging and fat suppression.

RESULTS

The B and B maps showed distribution similar to that of human brain, with increased B inhomogeneity near the nasal and ear areas and reduced B in the temporal lobe and brain stem regions, as expected in vivo. The metabolites' concentrations were verified by single-voxel spectroscopy, showing an average deviation of 11%. Fast spectroscopic imaging and imaging with fat suppression were demonstrated.

CONCLUSION

A 3D head-shaped phantom for human brain imaging and spectroscopic imaging in 7 T MRI was demonstrated, making it a realistic phantom for methodology development at 7 T.

摘要

目的

随着磁场强度向超高场（≥7T）发展，射频（B ）和静磁场（B ）的不均匀性增加，这进一步促使我们设计一个现实的人头形状的仿体，特别是用于波谱成像。这种仿体提供与人脑相似的图像，并作为开发和检查 MRI 方法的可靠工具。本研究旨在开发和描述一种填充有脑模拟代谢物的现实人头形状的仿体，用于在 7T MRI 扫描仪中进行 MRS 和磁共振波谱成像。

方法

构建了一个具有三个部分（模拟脑、肌肉和颅前脂质）的 3D 人头形状容器。该仿体设计为提供对加热、机械损伤和泄漏的稳定性，便于重新填充。对头的形状和琼脂糖混合物进行了优化，以提供类似于人脑的 B 和 B 分布和 T / T 弛豫值。包括 8 种脑组织模拟代谢物进行波谱分析。对局部波谱、快速波谱成像和脂肪抑制进行了评估。

结果

B 和 B 图谱显示出与人脑相似的分布，在鼻和耳区域附近的 B 不均匀性增加，在颞叶和脑干区域的 B 减少，这与体内预期的情况一致。通过单体素波谱验证了代谢物的浓度，平均偏差为 11%。展示了快速波谱成像和带有脂肪抑制的成像。

结论

证明了一种用于 7T MRI 人脑成像和波谱成像的 3D 人头形状的仿体，使其成为 7T 方法开发的现实仿体。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a0e4/7757235/e5007ca0cdac/NBM-34-e4421-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a0e4/7757235/7dd5efc42f42/NBM-34-e4421-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a0e4/7757235/1aaae6288f8b/NBM-34-e4421-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a0e4/7757235/faabe4f044e4/NBM-34-e4421-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a0e4/7757235/85e945f08436/NBM-34-e4421-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a0e4/7757235/609d27f35529/NBM-34-e4421-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a0e4/7757235/cb9c827e8292/NBM-34-e4421-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a0e4/7757235/e5007ca0cdac/NBM-34-e4421-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a0e4/7757235/7dd5efc42f42/NBM-34-e4421-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a0e4/7757235/1aaae6288f8b/NBM-34-e4421-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a0e4/7757235/faabe4f044e4/NBM-34-e4421-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a0e4/7757235/85e945f08436/NBM-34-e4421-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a0e4/7757235/609d27f35529/NBM-34-e4421-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a0e4/7757235/cb9c827e8292/NBM-34-e4421-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a0e4/7757235/e5007ca0cdac/NBM-34-e4421-g007.jpg

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