Watkins N G, Caldwell H D, Hackstadt T
J Bacteriol. 1987 Aug;169(8):3826-8. doi: 10.1128/jb.169.8.3826-3828.1987.
Chlamydial lipopolysaccharide (LPS) agglutinated mouse and rabbit erythrocytes but not human, guinea pig, or pronghorn antelope erythrocytes. Hemagglutination was not specific for Chlamydia spp., as rough LPSs from Coxiella burnetii and Escherichia coli also agglutinated erythrocytes from the same animal species. Nonagglutinated and agglutinated erythrocytes bound equivalent amounts of LPS, indicating that hemagglutination was not due to a specific interaction of chlamydial LPS with erythrocytes. Thus, hemagglutination by chlamydial LPS is not mediated by specific receptor-ligand interactions but is a property of the altered surface of the LPS-coated erythrocytes.
衣原体脂多糖（LPS）能凝集小鼠和兔的红细胞，但不能凝集人、豚鼠或叉角羚的红细胞。血凝作用并非衣原体属所特有，因为来自伯纳特立克次体和大肠杆菌的粗糙LPS也能凝集相同动物物种的红细胞。未凝集和凝集的红细胞结合等量的LPS，这表明血凝作用并非由于衣原体LPS与红细胞的特异性相互作用所致。因此，衣原体LPS的血凝作用不是由特异性受体-配体相互作用介导的，而是LPS包被红细胞表面改变的一种特性。
