Garrett Amy S, Loiselle Denis S, Han June-Chiew, Taberner Andrew J
Annu Int Conf IEEE Eng Med Biol Soc. 2020 Jul;2020:2557-2560. doi: 10.1109/EMBC44109.2020.9175474.
The heat production of cardiac muscle, determined by calorimetry, can be used as a measure of cardiac metabolism. However, heat produced while a muscle is actively-shortening, thereby performing force-length work, comprises both active and basal metabolic processes. In this paper, we present a method for post-experimental processing of calorimetric measurements of muscle heat production, that uncovers and compensates for the measured basal heat rate during work. In this method, the relationships between muscle length, velocity of length change and muscle heat output are coupled with a simulation of the measurement instrument, providing a model-based estimate of change of measured basal heat while the muscle is performing work. We demonstrate the use of this technique in an experiment conducted on a working cardiac muscle sample. The ability to identify the various components of heat release in these muscles provides useful insight into their mechanical and energetic capabilities.
通过量热法测定的心肌产热可作为心脏代谢的一种度量。然而，肌肉在主动缩短从而进行力-长度功时产生的热量，包含了主动和基础代谢过程。在本文中，我们提出了一种用于对肌肉产热的量热测量进行实验后处理的方法，该方法能够揭示并补偿工作期间测得的基础热率。在这种方法中，肌肉长度、长度变化速度与肌肉热输出之间的关系与测量仪器的模拟相结合，从而在肌肉做功时提供基于模型的测得基础热变化估计值。我们在对一块工作中的心肌样本进行的实验中展示了该技术的应用。识别这些肌肉中热释放的各个组成部分的能力，为深入了解其机械和能量能力提供了有用的见解。
