与呼吸暂停低通气指数相比，氧去饱和累积时间对心血管死亡率的预测性是否更佳？

Is Cumulative Time of Oxygen Desaturation a Better Predictor of Cardiovascular Mortality than Apnoea Hypopnoea Index?

作者信息

Sadr Nadi, Bin Yu Sun, Sutherland Kate, Cook Kristina, Dissanayake Hasthi, Cistulli Peter, Chazal Philip de

出版信息

Annu Int Conf IEEE Eng Med Biol Soc. 2020 Jul;2020:2788-2791. doi: 10.1109/EMBC44109.2020.9176554.

DOI:10.1109/EMBC44109.2020.9176554

Abstract

In this paper, we explored the link between sleep apnoea and cardiovascular disease (CVD) using a time-series statistical measure of sleep apnoea-related oxygen desaturation. We compared the performance of a hypoxic measure derived from the polysomnogram with the Apnoea Hypopnoea Index (AHI) in predicting CVD mortality in patients of the Sleep Heart Health Study.We estimated the relative cumulative time of SpO below 90% (T90) using pulse oximetry signals from polysomnogram recordings as the hypoxic measure of desaturation patterns. Then, the survival curves for hypoxia quintiles were evaluated for the prediction of CVD mortality and were compared with the results using AHI for prediction. We also calculated the Cox hazard ratios for T90 and AHI. Our results show that the T90 was a better predictor of CVD mortality outcomes than AHI.

摘要

在本文中，我们使用与睡眠呼吸暂停相关的氧饱和度降低的时间序列统计量，探讨了睡眠呼吸暂停与心血管疾病（CVD）之间的联系。我们在睡眠心脏健康研究的患者中，比较了源自多导睡眠图的低氧测量指标与呼吸暂停低通气指数（AHI）在预测CVD死亡率方面的表现。我们使用多导睡眠图记录中的脉搏血氧饱和度信号估计低于90%的血氧饱和度（SpO₂）的相对累积时间（T90），作为去饱和模式的低氧测量指标。然后，评估缺氧五分位数的生存曲线对CVD死亡率的预测情况，并与使用AHI进行预测的结果进行比较。我们还计算了T90和AHI的Cox风险比。我们的结果表明，T90在预测CVD死亡率结果方面比AHI表现更好。