Charles Perkins Centre, University of Sydney, Sydney, NSW 2006, Australia; School of Life and Environmental Sciences, University of Sydney, Sydney, NSW 2006, Australia.
Charles Perkins Centre, University of Sydney, Sydney, NSW 2006, Australia; School of Life and Environmental Sciences, University of Sydney, Sydney, NSW 2006, Australia; Sydney Nano Institute, University of Sydney, Sydney, NSW 2006, Australia.
Trends Biotechnol. 2021 May;39(5):505-518. doi: 10.1016/j.tibtech.2020.09.003. Epub 2020 Oct 2.
Surgically bypassing or replacing a severely damaged artery using a biodegradable synthetic vascular graft is a promising treatment that allows for the remodeling and regeneration of the graft to form a neoartery. Elastin-based structures, such as elastic fibers, elastic lamellae, and laminae, are key functional components in the arterial extracellular matrix. In this review, we identify the lack of elastin in vascular grafts as a key factor that prevents their long-term success. We further summarize advances in vascular tissue engineering that are focused on either de novo production of organized elastin or incorporation of elastin-based biomaterials within vascular grafts to mitigate failure and enhance enduring in vivo performance.
通过使用可生物降解的合成血管移植物绕过或替代严重受损的动脉是一种很有前途的治疗方法，它允许移植物的重塑和再生，形成新的动脉。基于弹性蛋白的结构，如弹性纤维、弹性板层和板层，是动脉细胞外基质中的关键功能成分。在这篇综述中，我们确定血管移植物中缺乏弹性蛋白是阻止其长期成功的关键因素。我们进一步总结了血管组织工程学的进展，这些进展集中在新合成有组织的弹性蛋白或在血管移植物中加入基于弹性蛋白的生物材料，以减轻失败并提高体内持久性能。
