肥大细胞和胸腺基质淋巴细胞生成素（TSLP）的表达与疱疹样皮炎的瘙痒强度呈正相关。
Mast cells and thymic stromal lymphopoietin (TSLP) expression positively correlates with pruritus intensity in dermatitis herpetiformis.
机构信息
School of Medicine and Life Sciences, University of Jinan-Shandong Academy of Medical Sciences, Jinan 250000, China, Shandong Provincial Hospital for Skin Diseases & Shandong Provincial Institute of Dermatology and Veneorology, Shandong First Medical University & Shandong Academy of Medical Sciences, Jinan, Shandong, China.
Shandong Provincial Hospital for Skin Diseases & Shandong Provincial Institute of Dermatology and Veneorology, Shandong First Medical University & Shandong Academy of Medical Sciences, Jinan, Shandong, China.
出版信息
Eur J Dermatol. 2020 Oct 1;30(5):499-504. doi: 10.1684/ejd.2020.3881.
BACKGROUND
Pruritus is one of the leading symptoms of dermatitis herpetiformis (DH), however, studies on the pathogenesis of pruritus are scarce. Currently, skin mast cells (MCs) have been indicated to play a role in pruritus in autoimmune bullous disease.
OBJECTIVE
To study the role of mast cells and related mediators involved in the pathogenesis of pruritus in DH.
MATERIALS & METHODS: The number of MCs and expression of histamine and thymic stromal lymphopoietin (TSLP) was investigated in lesions of 29 DH cases and 15 healthy skin donors by immunohistochemistry. Fourteen patients were assessed for severity of pruritus based on the Numeric Rating Scale and Pruritus Grading System. The levels of histamine and TSLP in the serum of 18 DH patients and 15 healthy controls were also investigated.
RESULTS
A significant increase in the number of MCs and degranulation was observed in DH lesions, which positively correlated with intensity of pruritus. In addition, skin TSLP but not histamine was shown to correlate with intensity of pruritus. No significant difference in expression of serum TSLP or histamine was observed between DH patients and healthy controls.
CONCLUSION
These results suggest that skin MCs and TSLP might be involved in the pathogenesis of pruritus in DH which should be further clarified in future studies.
背景
瘙痒是疱疹样皮炎（DH）的主要症状之一，然而，关于瘙痒发病机制的研究却很少。目前，皮肤肥大细胞（MCs）已被证实与自身免疫性大疱性疾病的瘙痒有关。
目的
研究肥大细胞及相关介质在 DH 瘙痒发病机制中的作用。
材料与方法
通过免疫组织化学法检测 29 例 DH 皮损和 15 例健康皮肤供体中 MCs 的数量和组胺及胸腺基质淋巴细胞生成素（TSLP）的表达。根据数字评分量表和瘙痒分级系统对 14 例患者的瘙痒严重程度进行评估。还检测了 18 例 DH 患者和 15 例健康对照者血清中组胺和 TSLP 的水平。
结果
DH 皮损中 MCs 数量增加和脱颗粒明显，与瘙痒强度呈正相关。此外，皮肤 TSLP 而非组胺与瘙痒强度相关。DH 患者与健康对照组血清 TSLP 或组胺的表达无显著差异。
结论
这些结果表明，皮肤 MCs 和 TSLP 可能参与 DH 瘙痒的发病机制，这需要在未来的研究中进一步阐明。
Zotero 插件