Gene-Xpert MTB RIF 在儿童和青少年肺外结核病诊断中的应用。
The use of Gene-Xpert MTB RIF in the diagnosis of extrapulmonary tuberculosis in childhood and adolescence.
机构信息
Instituto de Pediatria e Puericultura Martagão Gesteira, Universidade Federal do Rio de Janeiro, Rio de Janeiro, Brasil.
Instituto de Doenças do Tórax, Universidade Federal do Rio de Janeiro, Rio de Janeiro, Brasil.
出版信息
Rev Soc Bras Med Trop. 2020 Oct 5;53:e20200104. doi: 10.1590/0037-8682-0104-2020. eCollection 2020.
INTRODUCTION
Gene-Xpert MTB RIF (Xpert) is based on nucleic acid amplification by real-time polymerase chain reaction, which allows for the identification of Mycobacterium tuberculosis and rifampin resistance. We describe the use of Xpert for extrapulmonary tuberculosis (EPTB) in children and adolescents.
METHODS
A case series of two reference centers in Rio de Janeiro from 2014-2019.
RESULTS
The final diagnosis of EPTB was established in 11/36 (31%) patients, with five cases detectable by Xpert. For lymph node evaluation (9/11), diagnosis by Xpert occurred in 5/9 patients, all with caseous aspects.
CONCLUSIONS
Xpert can facilitate the rapid diagnosis of lymph node tuberculosis.
简介
Gene-Xpert MTB RIF（Xpert）基于实时聚合酶链反应的核酸扩增，可用于鉴定结核分枝杆菌和利福平耐药性。我们描述了 Xpert 在儿童和青少年肺外结核病（EPTB）中的应用。
方法
这是 2014 年至 2019 年在里约热内卢的两个参考中心进行的病例系列研究。
结果
最终诊断为 EPTB 的患者有 11/36（31%），其中 5 例可通过 Xpert 检测出来。在对淋巴结进行评估（9/11）时，Xpert 在 9/5 患者中检测到了诊断，所有患者均具有干酪样表现。
结论
Xpert 可有助于快速诊断淋巴结结核。
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