School of Biomedical Engineering, McMaster University, 1280 Main Street West, Hamilton, ON L8S 4L7, Canada.
Department of Engineering Physics, McMaster University, 1280 Main Street West, Hamilton, ON L8S 4L7, Canada.
ACS Nano. 2020 Oct 27;14(10):12341-12369. doi: 10.1021/acsnano.0c05937. Epub 2020 Oct 9.
The global COVID-19 pandemic has attracted considerable attention toward innovative methods and technologies for suppressing the spread of viruses. Transmission contaminated surfaces has been recognized as an important route for spreading SARS-CoV-2. Although significant efforts have been made to develop antibacterial surface coatings, the literature remains scarce for a systematic study on broad-range antiviral coatings. Here, we aim to provide a comprehensive overview of the antiviral materials and coatings that could be implemented for suppressing the spread of SARS-CoV-2 contaminated surfaces. We discuss the mechanism of operation and effectivity of several types of inorganic and organic materials, in the bulk and nanomaterial form, and assess the possibility of implementing these as antiviral coatings. Toxicity and environmental concerns are also discussed for the presented approaches. Finally, we present future perspectives with regards to emerging antimicrobial technologies such as omniphobic surfaces and assess their potential in suppressing surface-mediated virus transfer. Although some of these emerging technologies have not yet been tested directly as antiviral coatings, they hold great potential for designing the next generation of antiviral surfaces.
全球 COVID-19 大流行引起了人们对抑制病毒传播的创新方法和技术的极大关注。经污染表面传播已被认为是 SARS-CoV-2 传播的重要途径。尽管已经做出了巨大努力来开发抗菌表面涂层,但关于广谱抗病毒涂层的系统研究仍然很少。在这里,我们旨在全面概述可用于抑制 SARS-CoV-2 污染表面传播的抗病毒材料和涂层。我们讨论了几种类型的无机和有机材料的工作机制和有效性,包括块状和纳米材料形式,并评估了将这些材料作为抗病毒涂层的可能性。还针对所提出的方法讨论了毒性和环境问题。最后,我们提出了有关新兴抗菌技术(如全憎水表面)的未来展望,并评估了它们在抑制表面介导的病毒转移方面的潜力。尽管这些新兴技术中的一些尚未直接作为抗病毒涂层进行测试,但它们在设计下一代抗病毒表面方面具有很大的潜力。