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使用右心耳组织创建新肺动脉瓣技术的早期结果。

Early results of neopulmonary valve creation technique using right atrial appendage tissue.

作者信息

Onan Ismihan S, Ergün Servet, Özturk Erkut, Çelik Ekin C, Ayyıldız Pelin, Onan Burak

机构信息

Departments of Pediatric Cardiovascular Surgery Istanbul, Mehmet Akif Ersoy Thoracic and Cardiovascular Surgery Hospital, University of Health Sciences Turkey, Istanbul, Turkey.

Department of Pediatric Cardiology, Mehmet Akif Ersoy Thoracic and Cardiovascular Surgery Hospital, University of Health Sciences, Istanbul, Turkey.

出版信息

J Card Surg. 2020 Oct;35(10):2640-2648. doi: 10.1111/jocs.14860.

Abstract

INTRODUCTION

Various valve repair techniques have been described for prevention of pulmonary insufficiency (PI) during right ventricular outflow tract (RVOT) reconstruction with transannular patch. Herein, we present the early results of an alternative technique of neopulmonary valve reconstruction using right atrial appendage (RAA) tissue.

METHODS

Between October 2019 and December 2019, 12 patients with tetralogy of fallot (TOF) (n = 10), TOF-absent pulmonary valve (n = 1) and intact ventricular septum-pulmonary atresia (n = 1) underwent RVOT reconstruction with neopulmonary valve that was created using RAA tissue. Median age and weight of patients were 9.9 months (5 months-14 years) and 9.8 kg (6.2-47), respectively.

RESULTS

No mortality or major events developed. Postoperative echocardiography revealed none/trace PI in 11 patients and mild PI in 1 patient. Median right ventricle/left ventricle ratio was 0.46 (0.35-0.65) and RVOT gradient was 20 mm Hg (0-30). Median cardiopulmonary bypass and aortic clamping times were 121 minutes (81-178) and 94 minutes (59-138), respectively. Operative times revealed statistically significant learning curve pattern in terms of cardiopulmonary bypass (r = .568; P = .005) and aortic clamping times (r  = .635; P = .002). Median ventilation time, intensive care unit stay, and the length of hospital stay were 6 hours (2-48), 1 days (1-5), and 7 days (4-10), respectively. Longer perfusion time was not correlated with postoperative times. At median 6 months, echocardiography showed none/trivial PI in 11 patients and mild PI in one patient.

CONCLUSION

Early results showed that neopulmonary valve reconstruction using the RAA tissue may provide a reasonable alternative for RVOT reconstruction with transannular patch. But long-term results are needed.

摘要

引言

在使用跨环补片进行右心室流出道(RVOT)重建期间,已经描述了多种预防肺动脉瓣关闭不全(PI)的瓣膜修复技术。在此,我们展示了一种使用右心耳(RAA)组织进行新肺动脉瓣重建的替代技术的早期结果。

方法

在2019年10月至2019年12月期间,12例法洛四联症(TOF)患者(n = 10)、肺动脉瓣缺如的TOF患者(n = 1)和室间隔完整的肺动脉闭锁患者(n = 1)接受了使用RAA组织创建的新肺动脉瓣进行的RVOT重建。患者的中位年龄和体重分别为9.9个月(5个月至14岁)和9.8 kg(6.2至47)。

结果

未发生死亡或重大事件。术后超声心动图显示,11例患者无/微量PI,1例患者有轻度PI。右心室/左心室比值中位数为0.46(0.35至0.65),RVOT梯度为20 mmHg(0至30)。体外循环和主动脉阻断时间中位数分别为121分钟(81至178)和94分钟(59至138)。手术时间在体外循环(r = 0.568;P = 0.005)和主动脉阻断时间方面(r = 0.635;P = 0.002)显示出具有统计学意义的学习曲线模式。通气时间中位数、重症监护病房停留时间和住院时间分别为6小时(2至48)、1天(1至5)和7天(4至10)。较长的灌注时间与术后时间无关。在中位6个月时,超声心动图显示11例患者无/微量PI,1例患者有轻度PI。

结论

早期结果表明,使用RAA组织进行新肺动脉瓣重建可能为使用跨环补片进行RVOT重建提供一种合理的替代方法。但需要长期结果。

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