围手术期静脉注射利多卡因对非心脏手术后短期认知功能障碍发生率的影响：基于随机对照试验的荟萃分析。
Effect of perioperative intravenous lidocaine on the incidence of short-term cognitive function after noncardiac surgery: A meta-analysis based on randomized controlled trials.
机构信息
Anesthesia Department of Beijing Chao-Yang Hospital, Beijing, China.
Pharmacy Department of Beijing Chao-Yang Hospital, Beijing, China.
出版信息
Brain Behav. 2020 Dec;10(12):e01875. doi: 10.1002/brb3.1875. Epub 2020 Oct 12.
OBJECTIVES
Postoperative cognitive dysfunction is a debilitating postoperative complication. The perioperative neuroprotective effect of lidocaine has conflicting results.
METHODS
In this qualitative review of randomized controlled clinical trials on the perioperative use of lidocaine, we report the effects of intravenous lidocaine on brain function after noncardiac surgery. Studies were identified from PubMed, MEDLINE, and Cochrane Central Register.
RESULTS
Of the 453 retrieved studies, 4 randomized trials were included. No significant association between the use of lidocaine postoperative cognitive states was found (risk ratio 0.67; 95% CI -0.02 to 1.36; I 89%; p = .06).
CONCLUSIONS
Current evidence cannot suggest that perioperative intravenous use of lidocaine has pharmacological brain neuroprotection after noncardiac surgery. All the included studies were small-scale research, and the total number of participants was small; the results should be interpreted with caution.
目的
术后认知功能障碍是一种使人虚弱的术后并发症。利多卡因的围手术期神经保护作用存在相互矛盾的结果。
方法
在这项关于围手术期使用利多卡因的随机对照临床试验的定性综述中，我们报告了静脉内利多卡因对非心脏手术后脑功能的影响。研究从 PubMed、MEDLINE 和 Cochrane 中央登记处中确定。
结果
在检索到的 453 项研究中，有 4 项随机试验被纳入。未发现利多卡因术后认知状态之间存在显著关联（风险比 0.67；95%置信区间 -0.02 至 1.36；I 89%；p = 0.06）。
结论
目前的证据不能表明非心脏手术后围手术期静脉内使用利多卡因具有药物性脑神经保护作用。所有纳入的研究都是小规模研究，参与者总数较少；结果应谨慎解释。
Zotero 插件