The hypothalamus in Tourette's syndrome.

Although a recent report by Devinsky (1983) has suggested that dysfunction at a midbrain levels is most likely to underlie the major symptoms of Tourette's syndrome, several features of the disease including alterations in the severity of the disease during puberty and premenstrually, disorders of appetite, amelioration of tics with rise in body temperature, and sleep point to hypothalamic involvement in the pathophysiology of the disease.