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[肾移植术后可逆性硫唑嘌呤相关的骨髓增殖异常综合征]

[Reversible azathioprine associated dysmyeloproliferative syndrome after kidney allotransplantation].

作者信息

Bammatter F, Binswanger U, Fehr J

出版信息

Klin Wochenschr. 1987 Jul 1;65(13):620-4. doi: 10.1007/BF01726672.

Abstract

Three recipients of kidney allotransplants developed dysmyeloproliferative syndromes which were fully reversible after switching from azathioprine to cyclosporin A for immunosuppression. Similar bone marrow changes described in the literature progressed to leukemia. Whether the abnormalities observed in our patients could be early stages of the disease described in the literature and whether a fatal development can be prevented by changing the immunosuppressive therapy remains to be elucidated.

摘要

三名同种异体肾移植受者出现了骨髓增生异常综合征,在将免疫抑制药物从硫唑嘌呤换为环孢素A后,这些综合征完全可逆。文献中描述的类似骨髓变化会发展为白血病。我们患者中观察到的异常是否可能是文献中所述疾病的早期阶段,以及改变免疫抑制疗法是否可以预防致命发展,仍有待阐明。

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