University of Alabama at Birmingham School of Medicine, Birmingham, Alabama.
University of Maryland School of Medicine, Baltimore, Maryland.
Radiat Res. 2020 Dec 1;194(6):707-714. doi: 10.1667/RADE-20-00100.1.
Spatially fractionated radiotherapy (GRID) has been utilized primarily in the palliative and definitive treatment of bulky tumors. Delivered in the modern era primarily with megavoltage photon therapy, this technique offers the promise of safe dose escalation with potential immunogenic, bystander and microvasculature effects that can augment a conventionally fractionated course of radiotherapy. At the University of Maryland, an institutional standard has arisen to incorporate a single fraction of GRID radiation in large (>8 cm), high-risk soft tissue and osteosarcomas prior to a standard fractionated course. Herein, we report on the excellent pathologic responses and apparent safety of this regimen in 26 consecutive patients.
格点放射治疗（GRID）主要用于大块肿瘤的姑息治疗和根治性治疗。在现代，主要采用兆伏光子放射治疗来实施这种技术，它具有安全提高剂量的潜力，同时具有免疫原性、旁观者效应和微血管效应，可以增强常规分割放射治疗的效果。在马里兰大学，已经出现了一种机构标准，即在标准分割放射治疗之前，对大型（>8 厘米）、高危软组织和骨肉瘤患者进行单次 GRID 放射治疗。在此，我们报告了 26 例连续患者的良好病理反应和该方案的明显安全性。
