Department of Oncology, Fuyang Hospital of Anhui Medical University, Fuyang, China.
Cancer Invest. 2020 Nov;38(10):543-548. doi: 10.1080/07357907.2020.1824260. Epub 2020 Nov 24.
Duodenal adenocarcinoma is an uncommon, malignant tumor usually accompanied by a poor prognosis. We identified 3150 duodenal adenocarcinoma cases from the SEER database (1988-2013) to analyze clinical characteristics and outcomes. The Kaplan-Meier method was used to evaluate cancer-specific survival (CSS). Cox regression analysis was used to explore the prognostic factors of CSS. Adverse prognostic factors include higher tumor grade, later stage, tumor size ≥ 2cm, positive regional lymph nodes, and not undergoing surgical resection. Our results suggest, surgery is the optimal treatment for duodenal cancer, and combined radiotherapy does not improve survival.
十二指肠腺癌是一种罕见的恶性肿瘤，通常预后较差。我们从 SEER 数据库（1988-2013 年）中确定了 3150 例十二指肠腺癌病例，以分析其临床特征和结局。采用 Kaplan-Meier 方法评估癌症特异性生存率（CSS）。采用 Cox 回归分析探讨 CSS 的预后因素。不良预后因素包括肿瘤分级较高、分期较晚、肿瘤大小≥2cm、区域淋巴结阳性和未行手术切除。我们的研究结果表明，手术是治疗十二指肠癌的最佳方法，联合放疗并不能改善生存。
