长链非编码 RNA 和环状 RNA 在小细胞肺癌中的生物学功能。
Biological functions of long noncoding RNAs and circular RNAs in small-cell lung cancer.
机构信息
Department of Medical Oncology, Dr. B. R. Ambedkar Institute Rotary Cancer Hospital, All India Institute of Medical Sciences, Ansari Nagar, New Delhi 110029, India.
出版信息
Epigenomics. 2020 Oct;12(19):1751-1763. doi: 10.2217/epi-2020-0214. Epub 2020 Oct 19.
We aim to discuss comprehensively the role of long noncoding RNAs (lncRNAs) and circular RNAs (circRNAs) in small-cell lung cancer (SCLC) biology and their clinical utility as cancer biomarkers. We searched the scientific literature to select articles related to the role of lncRNAs and circRNAs in SCLC biology or as cancer biomarkers. We identified that a number of lncRNAs and circRNAs can regulate key biological processes involved in SCLC development, including cell proliferation, metastasis and chemoresistance mainly acting as miRNA sponges. Also, the expression of a few lncRNAs and circRNAs predicted survival outcome depicting their utility as prognostic biomarkers. Further investigations on the role of lncRNAs and circRNAs in SCLC tumors may yield novel therapeutic targets for SCLC.
我们旨在全面探讨长链非编码 RNA（lncRNA）和环状 RNA（circRNA）在小细胞肺癌（SCLC）生物学中的作用及其作为癌症生物标志物的临床应用价值。我们检索了科学文献，以选择与 lncRNA 和 circRNA 在 SCLC 生物学或作为癌症生物标志物中的作用相关的文章。我们发现，许多 lncRNA 和 circRNA 可以调节涉及 SCLC 发展的关键生物学过程，包括细胞增殖、转移和化学抗性，主要作为 miRNA 海绵起作用。此外，少数 lncRNA 和 circRNA 的表达可预测生存结果，表明它们可用作预后生物标志物。进一步研究 lncRNA 和 circRNA 在 SCLC 肿瘤中的作用可能为 SCLC 提供新的治疗靶点。
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