Department of Cardiology, Erciyes University School of Medicine, Kayseri, Turkey.
Department of Cardiology, Siyami Ersek Thoracic and Cardiovascular Surgery Center Training and Research Hospital, Istanbul, Turkey.
Blood Press Monit. 2021 Feb 1;26(1):1-7. doi: 10.1097/MBP.0000000000000490.
Methods using for determining the subclinical atherosclerosis have gained growing interest in the recent years. However, the effects of pseudo-hypertension on the parameters of subclinical atherosclerosis are uncertain. We aimed to evaluate the relationship between pseudo-hypertension and subclinical atherosclerosis in individuals diagnosed with pseudo-hypertension.
A total of 122 patients who underwent radial elective coronary angiography were included in the present study. These patients were divided into two groups based on the difference between invasive and noninvasive blood pressure (BP) measurements: pseudo-hypertension group who had a difference ≥15 mmHg in SBP or ≥10 mmHg in DBP levels between invasive and noninvasive measurements (n = 28), and the other group who did not have any difference as described on these levels (n = 94). In order to evaluate the subclinical atherosclerosis; flow-mediated dilatation (FMD), carotid intima-media thickness (IMT), pulse wave velocity (PWV), and augmentation index were recorded in all patients. Two groups were compared with respect to these parameters.
The median age of the pseudo-hypertension group was 76 years, while the median age of the other group was 63.5 years (P < 0.0001). The incidence of concomitant hypertension was higher in the pseudo-hypertension group as compared to the other group (P < 0.001). There was a significant difference in augmentation index, cardiac output, PWV, FMD, and IMT values between two groups (P = 0.016, P = 0.023, P <0.001, P < 0.001, P < 0.001, respectively).
The present results demonstrated that there was a strong correlation between pseudo-hypertension and the parameters of subclinical atherosclerosis; augmentation index, PWV, FMD, and carotids IMT.
近年来，用于确定亚临床动脉粥样硬化的方法引起了越来越多的关注。然而，假性高血压对亚临床动脉粥样硬化参数的影响尚不确定。我们旨在评估诊断为假性高血压的个体中假性高血压与亚临床动脉粥样硬化之间的关系。
本研究共纳入 122 例行桡动脉选择性冠状动脉造影的患者。根据侵入性和非侵入性血压（BP）测量之间的差异，将这些患者分为两组：收缩压或舒张压差异≥15mmHg 或≥10mmHg 的假性高血压组（n=28），以及这些水平无任何差异的另一组（n=94）。为了评估亚临床动脉粥样硬化；所有患者均记录血流介导的扩张（FMD）、颈动脉内膜中层厚度（IMT）、脉搏波速度（PWV）和增强指数。比较两组之间的这些参数。
假性高血压组的中位年龄为 76 岁，而另一组的中位年龄为 63.5 岁（P<0.0001）。假性高血压组合并高血压的发生率高于另一组（P<0.001）。两组之间的增强指数、心输出量、PWV、FMD 和 IMT 值存在显著差异（P=0.016、P=0.023、P<0.001、P<0.001、P<0.001）。
本研究结果表明，假性高血压与亚临床动脉粥样硬化的参数之间存在很强的相关性；增强指数、PWV、FMD 和颈动脉 IMT。
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