Fjellestad-Paulsen A, Wille S, Harris A S
Arch Dis Child. 1987 Jul;62(7):674-7. doi: 10.1136/adc.62.7.674.
A single blind dose response study of the effects of treatment with tablets containing 50-400 micrograms of desmopressin was conducted in 15 children with primary nocturnal enuresis. A dose response effect was seen, with the 100, 200, and 400 micrograms doses resulting in significantly more dry nights than when a placebo was used. The response after 200 micrograms was significantly different from that after 100 micrograms (p less than 0.02) but not from that after 400 micrograms. A randomised, double blind, double dummy, cross over study was then carried out in 30 children to compare the effects of a 20 micrograms dose given through a nasal pipette, a 200 micrograms tablet, and a placebo. The numbers of dry nights were significantly greater during both periods of treatment with desmopressin when compared with that using placebo, but there were no differences between the methods of taking the drug. After oral and nasal treatment 41% and 52%, respectively, of the patients improved by more than 50%. Nine children (31%) remained completely dry after treatment.
对15名原发性夜间遗尿症儿童进行了一项单盲剂量反应研究，以探讨含50 - 400微克去氨加压素片剂治疗的效果。观察到剂量反应效应，100微克、200微克和400微克剂量组的无尿床夜晚数显著多于使用安慰剂时。200微克剂量后的反应与100微克剂量后的反应有显著差异（p小于0.02），但与400微克剂量后的反应无显著差异。随后对30名儿童进行了一项随机、双盲、双模拟、交叉研究，比较经鼻滴管给予20微克剂量、200微克片剂和安慰剂的效果。与使用安慰剂相比，去氨加压素治疗的两个阶段无尿床夜晚数均显著增加，但给药方法之间无差异。口服和经鼻治疗后，分别有41%和52%的患者改善超过50%。9名儿童（31%）治疗后完全不再尿床。
