Goksu Suleyman Yasin, Ozer Muhammet, Beg Muhammad S, Sanford Nina Niu, Ahn Chul, Fangman Benjamin D, Goksu Busra B, Verma Udit, Sanjeevaiah Aravind, Hsiehchen David, Jones Amy L, Kainthla Radhika, Kazmi Syed M
Department of Internal Medicine, UT Southwestern Medical Center, Dallas, TX 75390, USA.
Division of Hematology and Oncology, UT Southwestern Medical Center, Dallas, TX 75390, USA.
Cancers (Basel). 2020 Oct 15;12(10):2990. doi: 10.3390/cancers12102990.
: We studied the effect of race and ethnicity on disease characteristics and survival in gastrointestinal neuroendocrine tumors. : The Surveillance, Epidemiology, and End Results database was used to select patients with non-pancreatic gastrointestinal neuroendocrine tumors diagnosed between 2004 and 2015. Trends in survival were evaluated among three groups: Hispanic, non-Hispanic White, and non-Hispanic Black. Kaplan-Meier and Cox regression methods were performed to calculate overall survival and cause-specific survival after adjusting for patient and tumor characteristics. A total of 26,399 patients were included in the study: 65.1% were non-Hispanic White, 19.9% were non-Hispanic Black, and 15% were Hispanic. Non-Hispanic White patients were more likely to be male (50.0%, < 0.001), older than 60 years (48.0%, < 0.001), and present with metastatic disease (17.7%, < 0.001). Non-Hispanic White patients had small intestine neuroendocrine tumors, while Hispanic and non-Hispanic Black patients had rectum neuroendocrine tumors as the most common primary site. Hispanic patients had better overall survival, while non-Hispanic Black patients had better cause-specific survival versus non-Hispanic White patients. This finding was confirmed on multivariable analysis where Hispanic patients had improved overall survival compared to non-Hispanic White patients (Hazard ratio (HR): 0.89 (0.81-0.97)), whereas non-Hispanic Black patients had better cause-specific survival compared to non-Hispanic White patients (HR: 0.89 (0.80-0.98)). : Race/ethnicity is an independent prognostic factor in patients with gastrointestinal neuroendocrine tumors.
我们研究了种族和族裔对胃肠道神经内分泌肿瘤的疾病特征及生存情况的影响。利用监测、流行病学和最终结果数据库选取了2004年至2015年间诊断为非胰腺胃肠道神经内分泌肿瘤的患者。评估了三组患者的生存趋势：西班牙裔、非西班牙裔白人以及非西班牙裔黑人。采用Kaplan-Meier法和Cox回归方法，在对患者和肿瘤特征进行校正后计算总生存率和病因特异性生存率。该研究共纳入26399例患者：65.1%为非西班牙裔白人，19.9%为非西班牙裔黑人，15%为西班牙裔。非西班牙裔白人患者更可能为男性（50.0%，<0.001）、年龄大于60岁（48.0%，<0.001）以及出现转移性疾病（17.7%，<0.001）。非西班牙裔白人患者以小肠神经内分泌肿瘤为主，而西班牙裔和非西班牙裔黑人患者以直肠神经内分泌肿瘤为最常见的原发部位。与非西班牙裔白人患者相比，西班牙裔患者总生存率更高，而非西班牙裔黑人患者病因特异性生存率更高。这一发现经多变量分析得到证实，与非西班牙裔白人患者相比，西班牙裔患者总生存率有所提高（风险比（HR）：0.89（0.81 - 0.97）），而非西班牙裔黑人患者与非西班牙裔白人患者相比病因特异性生存率更高（HR：0.89（0.80 - 0.98））。种族/族裔是胃肠道神经内分泌肿瘤患者的独立预后因素。
