Selzer A
Pacific Presbyterian Medical Center, Division of Cardiology, San Francisco, Calif.
Cardiology. 1987;74(5):369-75. doi: 10.1159/000174224.
Whereas the use of digitalis in atrial fibrillation is universally accepted, its administration in patients in sinus rhythm for its inotropic properties has recently been questioned. The risk of digitalis administration is high and may be unavoidable because of the occurrence of changes in sensitivity to digitalis. Benefits of digitalis are poorly defined. Hemodynamically digitalis is a weak inotropic agent. Clinical improvement is difficult to detect; furthermore, the role of long-term maintenance digitalis therapy appears questionable, inasmuch as several studies failed to show deterioration after digitalis therapy has been discontinued.
虽然洋地黄在心房颤动中的应用已被广泛接受，但近期有人对其在窦性心律患者中因其正性肌力特性而使用提出质疑。使用洋地黄的风险很高，由于对洋地黄的敏感性发生变化，这种风险可能不可避免。洋地黄的益处尚不明确。从血流动力学角度来看，洋地黄是一种弱的正性肌力药物。临床改善很难检测到；此外，长期维持洋地黄治疗的作用似乎存在疑问，因为多项研究未能显示在停用洋地黄治疗后病情会恶化。
