Microbiology Department-Research Institute Biomedical A Coruña (INIBIC), Hospital A Coruña (CHUAC), University of A Coruña (UDC), 15006 A Coruña, Spain.
Study Group on Mechanisms of Action and Resistance to Antimicrobials (GEMARA) of Spanish Society of Infectious Diseases and Clinical Microbiology (SEIMC), 28003 Madrid, Spain.
Viruses. 2020 Oct 16;12(10):1172. doi: 10.3390/v12101172.
At the end of 2019, a new disease appeared and spread all over the world, the COVID-19, produced by the coronavirus SARS-CoV-2. As a consequence of this worldwide health crisis, the scientific community began to redirect their knowledge and resources to fight against it. Here we summarize the recent research on viruses employed as therapy and diagnostic of COVID-19: (i) viral-vector vaccines both in clinical trials and pre-clinical phases; (ii) the use of bacteriophages to find antibodies specific to this virus and some studies of how to use the bacteriophages themselves as a treatment against viral diseases; and finally, (iii) the use of CRISPR-Cas technology both to obtain a fast precise diagnose of the patient and also the possible use of this technology as a cure.
2019 年末，一种新型疾病——由冠状病毒 SARS-CoV-2 引起的 COVID-19——出现并在全球范围内传播。由于这场全球卫生危机，科学界开始重新调整他们的知识和资源来与之抗争。在这里，我们总结了最近关于用于治疗和诊断 COVID-19 的病毒的研究：（i）临床和临床前阶段的病毒载体疫苗；（ii）噬菌体用于寻找针对该病毒的特异性抗体的应用，以及一些关于如何使用噬菌体本身作为治疗病毒性疾病的方法的研究；最后，（iii）CRISPR-Cas 技术的应用，既可以快速准确地诊断患者，也可以考虑将该技术用作治疗方法。
