Vanderas A P
Department of Pediatric Dentistry, School of Dental Medicine, University of Pittsburgh, PA.
Cleft Palate J. 1987 Jul;24(3):216-25.
A review of the literature pertaining to the incidence of cleft lip, cleft palate, and cleft lip and palate in different races is presented. The studies have been evaluated according to the method used to record the incidence rate. Half of the studies include in their base population livebirths, stillbirths, and abortions, or livebirths and stillbirths to record the incidence rate. In addition, in most of the studies, clefts with associated malformations and possible syndromes are included in the reported incidence. There is evidence, however, to suggest that the risk of developing clefts in stillbirths and abortions is three times as frequent as in livebirths and that clefts with associated malformations behave differently epidemiologically from clefts without associated malformations. It is suggested, therefore, that the incidence of cleft lip, cleft palate, and cleft lip and palate should be studied separately for each group, namely for livebirths, stillbirths, and abortions and should be reported separately for clefts without associated malformations, clefts with associated malformations, and syndromes. More research is needed to study the risk of developing clefts among the various groups that exhibit different epidemiologic behavior for each race.
本文对不同种族唇裂、腭裂及唇腭裂发病率的相关文献进行了综述。已根据记录发病率的方法对各项研究进行了评估。一半的研究在其基础人群中纳入活产儿、死产儿和流产儿,或仅纳入活产儿和死产儿来记录发病率。此外,在大多数研究中,伴有相关畸形和可能综合征的腭裂被纳入报告的发病率中。然而,有证据表明,死产儿和流产儿中发生腭裂的风险是活产儿的三倍,并且伴有相关畸形的腭裂在流行病学上与无相关畸形的腭裂表现不同。因此,建议应分别针对活产儿、死产儿和流产儿这几组人群,分别研究唇裂、腭裂及唇腭裂的发病率,并应分别报告无相关畸形的腭裂、伴有相关畸形的腭裂和综合征的发病率。需要开展更多研究,以探讨在每个种族中表现出不同流行病学行为的各类人群发生腭裂的风险。