Grusha Y O, Fedorov A A, Sheptulin V A, Fettser E I
Research Institute of Eye Diseases, Moscow, Russia.
I.M. Sechenov First Moscow State Medical University (Sechenov University), Moscow, Russia.
Vestn Oftalmol. 2020;136(6):19-25. doi: 10.17116/oftalma202013606119.
Palpebral eyelid weight implants are currently considered as the gold standard method for lagophthalmos correction. Manufactured from different precious metals, they have both benefits and drawbacks. The article presents the results of an experimental morphological study of biointegration of different eyelid weight implants used for correction of paralytic lagophthalmos.
To investigate biointegration properties of implants made of gold, platinum and platinum-gold alloy.
The study enrolled 4 Chinchilla rabbits (8 eyelids). Palpebral implants manufactured of gold, platinum and platinum-gold alloy were placed into the eyelids of the experimental animals. The morphological examination was performed 1 and 6 months after the implantation using paraffin sections.
Light microscopy revealed that the implant beds were surrounded by pronounced fibrovascular capsule of uneven thickness over the whole follow-up. The capsule formed after the placement of an implant made of gold and platinum alloy was more loose. However, the emerging connective tissue bridges of the capsule contributed to its immobilization in the tissues and lower risk of extrusion. No signs of an inflammatory and/or allergic reaction were observed in any of the cases.
The obtained results show that implants made of a 90/10% platinum-gold alloy and 999.9 fine platinum have similar biointegration in terms of morphological features during 6 months of the follow-up period.
眼睑重量植入物目前被认为是矫正兔眼症的金标准方法。由不同贵金属制成,它们既有优点也有缺点。本文介绍了用于矫正麻痹性兔眼症的不同眼睑重量植入物生物整合的实验形态学研究结果。
研究由金、铂和铂 - 金合金制成的植入物的生物整合特性。
该研究纳入了4只龙猫(8只眼睑)。将由金、铂和铂 - 金合金制成的眼睑植入物放入实验动物的眼睑中。植入后1个月和6个月使用石蜡切片进行形态学检查。
光学显微镜显示,在整个随访期间,植入床被厚度不均的明显纤维血管包膜包围。由金和铂合金制成的植入物放置后形成的包膜更疏松。然而,包膜中出现的结缔组织桥有助于其在组织中的固定以及降低挤出风险。在任何病例中均未观察到炎症和/或过敏反应的迹象。
所得结果表明,在随访期6个月内,由90/10%铂 - 金合金和999.9纯铂制成的植入物在形态特征方面具有相似的生物整合情况。